{"id":42732,"date":"2024-03-06T07:57:00","date_gmt":"2024-03-06T07:57:00","guid":{"rendered":"https:\/\/www.bensnaturalhealth.com\/blog\/?post_type=diabeteshealth&#038;p=42732"},"modified":"2026-04-10T05:01:36","modified_gmt":"2026-04-10T05:01:36","slug":"jardiance-drug-interactions","status":"publish","type":"diabeteshealth","link":"https:\/\/www.bensnaturalhealth.com\/blog\/diabetes-health\/jardiance-drug-interactions\/","title":{"rendered":"6 Drugs That Should Not Be Taken With Jardiance (Empagliflozin)"},"content":{"rendered":"\n<p>Jardiance (drug name empagliflozin) is an oral medication used to treat type 2 diabetes.&nbsp;<\/p>\n\n\n\n<p>It works by reducing the amount of sugar absorbed by your kidneys and excreting it in your urine.&nbsp;<\/p>\n\n\n\n<p>If you&rsquo;ve been prescribed Jardiance to help manage your diabetes, it&rsquo;s important to know which drugs might interact with it.&nbsp;<\/p>\n\n\n\n<p>Drug interactions may cause a range of symptoms, from mild to severe.&nbsp;<\/p>\n\n\n\n<p>Your healthcare provider and pharmacist can provide guidance to help avoid drug interactions, but knowledge is power, especially when it comes to your health.&nbsp;<\/p>\n\n\n\n<p>In this article, we&rsquo;ll review some of the most common drugs that should not be taken with Jardiance.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-6-potential-drug-interactions-with-jardiance\">6 potential drug interactions with Jardiance<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-1-insulin\">1) Insulin<\/h2>\n\n\n\n<p>Taking Jardiance in addition to medications that can cause low blood sugar &ndash; such as insulin &ndash; increases your risk of low blood sugar.<\/p>\n\n\n\n<p>If your healthcare provider prescribes Jardiance and you&rsquo;re already taking any type of insulin (e.g., long-acting like insulin detemir, regular insulin, or rapid-acting insulin like insulin aspart), they might need to reduce or adjust your dose of insulin.<\/p>\n\n\n\n<p>If you develop signs of low blood sugar while taking Jardiance and insulin, reach out to your healthcare provider for guidance.&nbsp;<\/p>\n\n\n\n<p>Some of the most common symptoms of low blood sugar include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Fast heartbeat<\/li>\n\n\n\n<li>Shaking<\/li>\n\n\n\n<li>Sweating<\/li>\n\n\n\n<li>Nervousness or anxiety<\/li>\n\n\n\n<li>Irritability or confusion<\/li>\n\n\n\n<li>Dizziness<\/li>\n\n\n\n<li>Hunger<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-2-sulfonylureas\">2) Sulfonylureas<\/h2>\n\n\n\n<p>After insulin, sulfonylureas (a group of drugs used to treat diabetes) are generally considered to have the highest risk of causing low blood sugar.&nbsp;<\/p>\n\n\n\n<p>Sulfonylureas stimulate your pancreas to produce more insulin, the hormone that lowers your blood sugar level.<\/p>\n\n\n\n<p>Like insulin, taking sulfonylureas along with Jardiance increases your risk of developing low blood sugar.&nbsp;<\/p>\n\n\n\n<p>Some of the most well-known sulfonylureas include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Glipizide&nbsp;<\/li>\n\n\n\n<li>Glimepiride<\/li>\n\n\n\n<li>Glyburide<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-3-glinides\">3) Glinides<\/h2>\n\n\n\n<p>Glinides are a class of diabetes medications that increase insulin secretion (similar to sulfonylureas).&nbsp;<\/p>\n\n\n\n<p>Because they increase your risk of low blood sugar, glinides may interact with Jardiance and cause worsening low blood sugar compared to each drug by itself.<\/p>\n\n\n\n<p>Glinides are taken before meals and help by reducing the rise in blood sugar after eating.&nbsp;<\/p>\n\n\n\n<p>Glinides aren&rsquo;t as commonly used as other medications like metformin, but they are still used because of their efficacy.&nbsp;<\/p>\n\n\n\n<p>The two drugs classified as glinides are:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Prandin (Repaglinide)&nbsp;<\/li>\n\n\n\n<li>Starlix (Nateglinide)<\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-4-certain-diuretics\">4) Certain diuretics<\/h2>\n\n\n\n<p>Jardiance increases your risk of becoming dehydrated, which can lead to kidney problems and other adverse side effects.&nbsp;<\/p>\n\n\n\n<p>If you&rsquo;re taking other medications to reduce fluid buildup from your body, your risk of dehydration and kidney damage is even higher.<\/p>\n\n\n\n<p>Diuretics are a class of medications used to treat high blood pressure, heart failure, and other conditions that are worsened by fluid retention. Diuretics are often referred to as &ldquo;water pills.&rdquo;<\/p>\n\n\n\n<p>The most common class of diuretics used are thiazide diuretics, which <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2904515\/\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">studies<\/a> show work by blocking your kidneys from taking up sodium (salt) and increasing the amount of fluid excreted in your urine, which lowers blood pressure and reduces fluid retention.<\/p>\n\n\n\n<p>Some diuretics that can cause dehydration and may interact with Jardiance are:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/blog.bensnaturalhealth.com\/general-health\/furosemide-side-effects-in-elderly\/\" target=\"_blank\" rel=\"noreferrer noopener\">Furosemide<\/a> (brand name Lasix)<\/li>\n\n\n\n<li>Hydrochlorothiazide (Microzide)<\/li>\n\n\n\n<li><a href=\"https:\/\/blog.bensnaturalhealth.com\/general-health\/spironolactone-foods-to-avoid\/\" target=\"_blank\" rel=\"noreferrer noopener\">Spironolactone<\/a> (Aldactone)<\/li>\n\n\n\n<li>Chlorothiazide (Diuril)<\/li>\n\n\n\n<li>Chlorthalidone<\/li>\n\n\n\n<li>Indapamide<\/li>\n\n\n\n<li>Metolazone<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-5-other-sglt2-inhibitors\">5) Other SGLT2 inhibitors<\/h2>\n\n\n\n<p>Jardiance is in a class of diabetes medications called SGLT2 inhibitors. Taking Jardiance with other SGLT2 inhibitors can increase your risk of developing both minor and <a href=\"https:\/\/blog.bensnaturalhealth.com\/diabetes-health\/jardiance-side-effects\/\" target=\"_blank\" rel=\"noreferrer noopener\">more severe side effects<\/a>, so they shouldn&rsquo;t be taken together.&nbsp;<\/p>\n\n\n\n<p>Besides Jardiance, the other SGLT2 inhibitors are:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Brenzavvy (bexagliflozin)<\/li>\n\n\n\n<li><a href=\"https:\/\/blog.bensnaturalhealth.com\/diabetes-health\/invokana-vs-jardiance\/\" target=\"_blank\" rel=\"noreferrer noopener\">Invokana (canagliflozin)<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/blog.bensnaturalhealth.com\/diabetes-health\/farxiga-vs-jardiance\/\" target=\"_blank\" rel=\"noreferrer noopener\">Farxiga (dapagliflozin)<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/blog.bensnaturalhealth.com\/diabetes-health\/steglatro-side-effects\/\" target=\"_blank\" rel=\"noreferrer noopener\">Steglatro (ertugliflozin)<\/a><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-6-lithium\">6) Lithium<\/h2>\n\n\n\n<p>Taking SGLT2 inhibitors like Jardiance impacts your body&rsquo;s clearance of lithium, a medication used to treat bipolar disorder and other mental health conditions.&nbsp;<\/p>\n\n\n\n<p>According to a <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7304652\/\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">study<\/a>, medications like Jardiance can lower blood levels of lithium, which can reduce its efficacy at treating mental health conditions they&rsquo;re prescribed to treat.<\/p>\n\n\n\n<p>If you&rsquo;re taking other medications for mental health conditions besides lithium, there is no need to discontinue them since lithium is the only mental health medication known to interact with SGLT2 inhibitors.&nbsp;<\/p>\n\n\n\n<p>Never stop taking a prescribed medication without first speaking with your healthcare provider since doing so can lead to potentially harmful side effects in some instances.<\/p>\n\n\n\n    <div class=\"row lazy inline-optin\" data-src=\"https:\/\/www.bensnaturalhealth.com\/blog\/wp-content\/uploads\/2019\/11\/ebook-banner-wood-bg.jpg\"> \n   \n    <div class=\"col-12 col-md-8\">\n    <h3 style=\"font-weight:600; font-size:32px\">Sign Up For Our Newsletter! <\/h3>\n    <ul>\n    <li>Receive 10% off our best-selling supplements <\/li><li>Get Your FREE Diabetes Diet Plan <\/li><li>Be the first to hear about sales and promotions <\/li><li> Stay up to date on our latest health news<\/li>    <\/ul>\n    <form action=\"#\" method=\"post\" id=\"bnh-iniline-leadgen-1\" class=\"form inline-leadgen\" onsubmit=\"return false\">\n        <input type=\"hidden\" name=\"list\" value=\"daily_newsletter_mainlist\">\n        <div class=\"row\">\n            <div class=\"col-7\">\n                 <input type=\"email\" name=\"email\" placeholder=\"Enter Email Address\">\n                \n            <\/div>\n            <div class=\"col-5\">\n                <input type=\"hidden\" name=\"action\" value=\"bnh_subscribe\">\n                <input type=\"hidden\" name=\"source\" value=\"Blog Inline Leadgen\">\n                <input type=\"hidden\" name=\"event\" value=\"15 Food Blood Sugar eBook Download\">\n                <input type =\"hidden\" name =\"mprovider\" value=\"klaviyo\" >\n                <input type=\"submit\" name=\"submit\" value=\"Download Now\" class=\"cta\"  id=\"leadgen-subscribe-button-1\" >\n                 <script>\n  \/*check option and subscrbe *\/\n    jQuery(document).ready(function (){\n        bensnaturalhealth.subscribe('#leadgen-subscribe-button-1');\n    });\n<\/script>\n        <\/div>\n        <\/div>\n        <div class=\"row\">\n            <div class=\"col-12\">\n            <p class=\"errorEmail error\" style=\"display: none;\"><\/p>\n                 <p class=\"success\" style=\"display: none;\">Thank You! You're All Set! Please Check Your Email for Further Instruction. Please allow 10-15 minutes for your eBook to arrive.<\/p>\n            <\/div>\n        <\/div>\n        \n        \n        <p class=\"small-info\"> By clicking &ldquo;Download Now&rdquo;, I agree to Ben's Natural Health Terms and Conditions and Privacy Policy.<\/p>\n    <\/form>\n    <\/div>\n    <div class=\"col-12 col-md-4 no-pad-left hidden-xs\">\n    <img data-src=\"https:\/\/blog.bensnaturalhealth.com\/wp-content\/uploads\/2024\/02\/Diabetes-Blood-Sugar-cover.png\" class=\"img-center-xs img-responsive lazy hidden-xs\" alt=\"\">\n    <\/div>\n    <\/div>\n\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-when-to-talk-to-your-doctor-about-a-jardiance-medication-interaction\">When to talk to your doctor about a Jardiance medication interaction<\/h2>\n\n\n\n<p>If you think you&rsquo;re experiencing a Jardiance medication interaction, you should reach out to your prescribing healthcare provider immediately.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-the-most-likely-signs-and-symptoms-of-a-medication-interaction-can-include\">The most likely signs and symptoms of a medication interaction can include:<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Signs of low blood sugar <\/strong>include dizziness, shakiness, sweating, and low blood sugar readings during at-home testing.<\/li>\n\n\n\n<li><strong>Signs of dehydration<\/strong> can include reduced urine output, increased thirst, strong-smelling and dark-colored urine, dry mouth, and fatigue.<\/li>\n\n\n\n<li><strong>Worsening mental health symptoms (if you&rsquo;re taking lithium for mental health disorders like bipolar disorder)<\/strong>. These worsening symptoms can include extreme mood fluctuations, mania (feeling overly elated or happy), being easily agitated, or having hallucinations.<\/li>\n<\/ul>\n\n\n\n<p>If you develop signs of a kidney injury or kidney failure from dehydration (which can be worsened by Jardiance interactions), consult emergency medical attention immediately.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-signs-of-kidney-problems-that-are-alarming-and-require-immediate-attention-include\"><strong>Signs of kidney problems that are alarming and require immediate attention include:<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Very little urine output<\/li>\n\n\n\n<li>Increased blood pressure<\/li>\n\n\n\n<li>Swelling of your legs, ankles, or around your eyes<\/li>\n\n\n\n<li>Confusion<\/li>\n\n\n\n<li>Shortness of breath<\/li>\n\n\n\n<li>Chest pain<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-conclusion\">Conclusion<\/h2>\n\n\n\n<p><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Jardiance is the brand name for empagliflozin, an oral medication used to treat type 2 diabetes.<\/li>\n\n\n\n<li>Certain medications are known to interact with Jardiance, including insulin, sulfonylureas, glinides, diuretics, lithium, and other medications in the same drug class as Jardiance (SGLT2 inhibitors).<\/li>\n\n\n\n<li>If you suspect a possible medication interaction with Jardiance, it is advisable to promptly consult your healthcare provider for guidance.<\/li>\n\n\n\n<li>If you develop severe signs of dehydration and kidney problems, it warrants emergency medical attention.<\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-explore-more\">Explore More<\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/blog.bensnaturalhealth.com\/diabetes-health\/jardiance-foods-to-avoid\/\" target=\"_blank\" rel=\"noreferrer noopener\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"217\" src=\"https:\/\/blog.bensnaturalhealth.com\/wp-content\/uploads\/2023\/08\/foods-to-eat-and-avoid-while-taking-jardiance-1024x217.jpg\" alt=\"foods to avoid while taking jardiance\" class=\"wp-image-40451\" srcset=\"https:\/\/www.bensnaturalhealth.com\/blog\/wp-content\/uploads\/2023\/08\/foods-to-eat-and-avoid-while-taking-jardiance-1024x217.jpg 1024w, https:\/\/www.bensnaturalhealth.com\/blog\/wp-content\/uploads\/2023\/08\/foods-to-eat-and-avoid-while-taking-jardiance-300x64.jpg 300w, https:\/\/www.bensnaturalhealth.com\/blog\/wp-content\/uploads\/2023\/08\/foods-to-eat-and-avoid-while-taking-jardiance-768x163.jpg 768w, https:\/\/www.bensnaturalhealth.com\/blog\/wp-content\/uploads\/2023\/08\/foods-to-eat-and-avoid-while-taking-jardiance.jpg 1180w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure>\n\n\n\n<p><a href=\"https:\/\/blog.bensnaturalhealth.com\/diabetes-health\/jardiance-foods-to-avoid\/\" target=\"_blank\" rel=\"noreferrer noopener\">10 Foods To Eat and Avoid While Taking Jardiance<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Jardiance (drug name empagliflozin) is an oral medication used to treat type 2 diabetes.&nbsp; It [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":42757,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false},"tags":[],"diabetes_categories":[91],"class_list":["post-42732","diabeteshealth","type-diabeteshealth","status-publish","has-post-thumbnail","hentry","diabetes_categories-diabetes-medication"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.3 (Yoast SEO v27.2) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>6 Drugs That Should Not Be Taken With Jardiance (Empagliflozin) - Ben&#039;s Natural Health<\/title>\n<meta name=\"description\" content=\"Find out what drugs should not be taken with Jardiance, the signs and symptoms of a drug interaction, and when to see a doctor for medication interactions.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.bensnaturalhealth.com\/blog\/diabetes-health\/jardiance-drug-interactions\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"6 Drugs That Should Not Be Taken With Jardiance (Empagliflozin) - Ben&#039;s Natural Health\" \/>\n<meta property=\"og:description\" content=\"Find out what drugs should not be taken with Jardiance, the signs and symptoms of a drug interaction, and when to see a doctor for medication interactions.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.bensnaturalhealth.com\/blog\/diabetes-health\/jardiance-drug-interactions\/\" \/>\n<meta property=\"og:site_name\" content=\"Ben&#039;s Natural Health\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-10T05:01:36+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.bensnaturalhealth.com\/blog\/wp-content\/uploads\/2024\/03\/what-drugs-should-not-be-taken-with-jardiance.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1180\" \/>\n\t<meta property=\"og:image:height\" content=\"250\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":[\"WebPage\",\"MedicalWebPage\"],\"@id\":\"https:\/\/www.bensnaturalhealth.com\/blog\/diabetes-health\/jardiance-drug-interactions\/\",\"url\":\"https:\/\/www.bensnaturalhealth.com\/blog\/diabetes-health\/jardiance-drug-interactions\/\",\"name\":\"6 Drugs That Should Not Be Taken With Jardiance (Empagliflozin) - Ben&#039;s Natural Health\",\"isPartOf\":{\"@id\":\"https:\/\/www.bensnaturalhealth.com\/blog\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.bensnaturalhealth.com\/blog\/diabetes-health\/jardiance-drug-interactions\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.bensnaturalhealth.com\/blog\/diabetes-health\/jardiance-drug-interactions\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.bensnaturalhealth.com\/blog\/wp-content\/uploads\/2024\/03\/what-drugs-should-not-be-taken-with-jardiance.jpg\",\"datePublished\":\"2024-03-06T07:57:00+00:00\",\"dateModified\":\"2026-04-10T05:01:36+00:00\",\"description\":\"Find out what drugs should not be taken with Jardiance, the signs and symptoms of a drug interaction, and when to see a doctor for medication interactions.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.bensnaturalhealth.com\/blog\/diabetes-health\/jardiance-drug-interactions\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.bensnaturalhealth.com\/blog\/diabetes-health\/jardiance-drug-interactions\/\"]}],\"author\":{\"@type\":\"Person\",\"name\":\"Diana Gariglio-Clelland\",\"url\":\"https:\/\/www.bensnaturalhealth.com\/blog\/author\/diana-gariglio-clelland\/\",\"jobTitle\":\"Registered Dietitian (RD) and Certified Diabetes Care & Education Specialist (CDCES)\",\"worksFor\":{\"@type\":\"Organization\",\"name\":\"Ben's Natural Health\"},\"sameAs\":[\"https:\/\/www.linkedin.com\/in\/dianagariglioclelland\"]},\"medicalAudience\":{\"@type\":\"MedicalAudience\",\"requiredMinAge\":40},\"specialty\":[\"https:\/\/schema.org\/Urologic\",\"https:\/\/schema.org\/Geriatric\"],\"citation\":[\"Frampton JE. Empagliflozin: A Review in Symptomatic Chronic Heart Failure. Drugs. 2022 Nov;82(16):1591-1602. doi: 10.1007\/s40265-022-01778-0. Epub 2022 Nov 14. PMID: 36374374.\",\"CDC. Low Blood Sugar (Hypoglycemia).\",\"Diabetes.co.uk. Prandial Glucose Regulators (Glinides).\",\"Duarte JD, Cooper-DeHoff RM. Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics. Expert Rev Cardiovasc Ther. 2010 Jun;8(6):793-802. doi: 10.1586\/erc.10.27. PMID: 20528637; PMCID: PMC2904515.\",\"National Kidney Foundation. Sodium-glucose cotransporter-2 (SGLT2) inhibitors.\",\"Armstrong GP. Empagliflozin-Mediated Lithium Excretion: A Case Study and Clinical Applications. Am J Case Rep. 2020 Jun 10;21:e923311. doi: 10.12659\/AJCR.923311. 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