Prostate cancer can spread to nearby areas (stage III disease), including the seminal vesicles. Following a diagnosis of locally advanced prostate cancer, there a range of therapeutic options to treat the disease. <\/p>\n\n\n\n
Hormone therapy<\/a>, surgery, and radiation therapy<\/a> are the primary treatments offered to men with stage III prostate cancer. In some cases, a combination of these therapies is required for an optimal outcome or to manage treatment resistance.<\/p>\n\n\n\n Here, we discuss the characteristics of stage III prostate cancer, the associated risk factors, its diagnosis, and treatment. We make significant contrasts with other prostate cancer stages to highlight the current challenges in the treatment of this stage of prostate cancer.\u00a0<\/p>\n\n\n\n Prostate cancer is a form of malignancy that starts in the prostate gland, a small gland located between the bladder and the penis. The prostate plays an essential role in normal sexual function and fertility. <\/p>\n\n\n\n As men age, the cells in this gland may transform into cancer cells that spread to other parts of the body (locally advanced disease). In the early stages of the disease, it develops slowly, while locally advanced diseases grow faster with an increased risk of distant spread. <\/p>\n\n\n\n Some men present with advanced disease that grows and spread more rapidly. Treatment resistance<\/a> may develop in some patients, leading to lethal outcomes.\u00a0\u00a0<\/p>\n\n\n\n Usually, clinicians use staging to describe the extent to which prostate cancer has advanced and spread to other organs. The three main stages include stages I (1), II (2), III (3), and IV (4). <\/p>\n\n\n\n An alphabetical notation is used to split some stages into levels of severity. When prostate cancer is stage 3, the tumor within the prostate gland<\/a> has spread through the local tissues. This local spread often affects the seminal vesicles<\/a>, two glands that secrete some of the fluid that make up the volume of semen.<\/p>\n\n\n\n <\/p>\n\n\n\n [bensnaturalhealthIinlineLeadGen id =”1″ list_name=”funnel_a2_aatp\u201d]<\/p>\n\n\n\n <\/p>\n\n\n\n The incidence of prostate cancer and the progression of advanced disease correlates with certain risk factors. The mechanisms underlying this association remains an active area of research. <\/p>\n\n\n\n However, it is now accepted that genetic, environmental, and social factors influence the risk of prostate cancer. For instance, race, age, and family history are strong predictors of a prostate cancer diagnosis (Crawford, 2003; Ferlay et al., 2010; Ferris-i-Tortajada et al., 2011).\u00a0<\/p>\n\n\n\n Over 20% of patients with prostate cancer have a first-degree relative with the disease, highlighting the importance of genetics. Further, increasing age is associated with a higher rate of the disease. Men over the age of 65-years of age are more likely to get a prostate cancer diagnosis<\/a> than their younger counterparts. <\/p>\n\n\n\n Concerning race, black men are more likely to get a prostate diagnosis compared to men of other races. They are equally likely to be diagnosed with a more aggressive disease compared to men of other races. This increased risk may originate from the combinatory action of genetic, environmental, and social factors (Hatcher et al., 2009). However, the underlying mechanisms remain somewhat controversial.<\/p>\n\n\n\n Other factors, like chemical agents, influence the risk of several cancers. For prostate cancer, alcohol abuse and smoking increase the risk of prostate cancer. Notably, the risk of prostate cancer increases with the number of cigarettes smoked daily. A range of organic compounds (for example, insecticides) exhibits an association with prostate cancer risk<\/a>, albeit weaker than alcohol and cigarettes.<\/p>\n\n\n\n Lifestyle is perhaps the strongest predictor of a prostate cancer diagnosis. Physical inactivity and calorie-rich diets increase the risk of prostate cancer (Barnard et al., 2008). The metabolic disorder arising from these lifestyle changes mediate sustained prostate inflammation<\/a> to increase the risk of oxidative damage and prostate cancer.<\/p>\n\n\n\n TNM staging is a system used by clinicians to classify the development of cancer in the body. Oncologists around the world use the size, location, and extent of spread to assign a grade to a prostate tumor<\/a>. <\/p>\n\n\n\n The size (T), spread to local lymph nodes (N), and spread to distant tissues (M) are combined in the TNM system<\/a> (American Joint Committee on Cancer) to derive a 4-tier grade for the tumor. The score for each element derives from a set of pre-determined criteria and thresholds.<\/p>\n\n\n\n These include the following stages:<\/p>\n\n\n\n This stage of prostate cancer (called T3 or stage III) describes locally advanced disease. With stage III, the prostate cancer has spread to nearby tissues. <\/p>\n\n\n\n However, at stage III no other organs are affected except for local spread to the seminal vesicles. It is the stage before cancer invades nearby lymph nodes<\/a> or other areas of the body, leading to stage IV cancer. <\/p>\n\n\n\n As stage IV is untreatable and difficult to manage, stage III often requires immediate treatment decisions to reduce the risk of progression.<\/p>\n\n\n\n Stage III prostate cancer is subdivided into three categories, depending on the extent of the local spread. These subgroups are:<\/p>\n\n\n\n Typically, Stage T3c has increased risk of developing into the last stage of prostate cancer, reaching nearby lymph nodes and potentially distant metastasis<\/a>. Cancer cells in the lymph nodes can quickly spread to other parts of the body through the circulatory system.<\/p>\n\n\n\n Because stage 3 prostate cancer is still within the prostate area and does not affect other body parts, symptoms majorly originate from the prostate gland and pelvic area. In some cases, patients may experience systemic symptoms and pain.<\/p>\n\n\n\n Stage 3 symptoms usually include urinary and sexual problems:<\/p>\n\n\n\n The expansion of the prostate gland due to cancer growth puts pressure on the bladder and the urethra. This pressure of nearby organs can cause urinary problems, including weak urine flow, frequent urination<\/a>, urine retention, painful urination<\/a>, and blood in the urine.<\/p>\n\n\n\n Because of the urinary complications associated with this stage of prostate cancer, some men experience a persistent urinary infection.\u00a0\u00a0<\/p>\n\n\n\n Generally, the severity of these symptoms will vary between people and partly depend on the category of stage III (a-c) of cancer. Further, the symptoms may indicate other prostate conditions like prostatitis<\/a> and benign prostatic hyperplasia<\/a>.<\/p>\n\n\n\n Because of the urinary complications associated with this stage of prostate cancer, some men experience a persistent urinary infection<\/a>.\u00a0\u00a0<\/p>\n\n\n\n The severity of these symptoms will vary between people and partly depend on the category of stage III (a-c) of cancer. The symptoms may indicate other prostate conditions like prostatitis and benign prostatic hyperplasia.\u00a0<\/p>\n\n\n\n The diagnosis of stage 3 prostate cancer is given after a battery of the test has been taken. They help determine the presence of cancer, the size of the tumor, the location in the gland, and the extent of spread to nearby tissues.<\/p>\n\n\n\n Your doctor may use the results of some or all of the following tests.<\/p>\n\n\n\n PSA level can indicate the presence of cancer. Healthy prostate cells produce and a secret small amount of PSA in the blood. PSA level<\/a> in the blood rises as the prostate enlarges, and the prostate integrity is damaged by cancer.<\/p>\n\n\n\n The doctor can investigate the presence of hard or lumpy areas through the wall of the rectum.<\/p>\n\n\n\n MRI scan<\/a> creates a detailed image of the prostate and the nearby tissues. This scan reveals the presence of cancer and informs the clinical decision for biopsy.<\/p>\n\n\n\n A thin needle is used to extract small samples from the prostate. This tissue is investigated by a pathologist to check for cancer and determine its characteristics like the Gleason grade. Treatments for prostate cancer can only proceed after the analysis of a prostate biopsy<\/a>.<\/p>\n\n\n\n This scan helps determine whether prostate cancer has spread to distant organs, especially nearby lymph nodes or bones.<\/p>\n\n\n\n Some genetic tests are available to determine the risk of developing advanced diseases and the rate of metastasis.<\/p>\n\n\n\n Once the cancer is staged, the doctor will use this information in conjunction with other tests to make a treatment decision.<\/p>\n\n\n\n Currently, there is no single treatment that can robustly treat stage 3 prostate cancer. The appropriate treatment will depend on the individual case but will often involve one or a combination of the following treatments.<\/p>\n\n\n\n Treatment options for advanced prostate cancer<\/a> vary based on individual factors, including age, overall health, and previous treatments. Surgery reduces disease-specific mortality, risk of disease progression, and metastasis (Bill-Axelson et al., 2005).\u00a0<\/p>\n\n\n\n In some cases, prostate cancer cells may develop resistance to androgen deprivation therapy (ADT), impacting its long-term effectiveness. At the same time, there is evidence that stage T3a or lower, with less than 8 Gleason score<\/a> and PSA lower than 20 ng\/ml, benefit most from surgical therapy (Mongiat-Artus et al., 2009; Palisaar and Noldus, 2008). <\/p>\n\n\n\n In a comparative study, Gibert et al. demonstrated that surgery and radiation therapy have a comparable level of disease-specific mortality and risk of disease progression (Giberti et al., 2009).<\/p>\n\n\n\n These treatments can cause side effects, including:<\/p>\n\n\n\n Stage 3 prostate cancer cause symptoms, such as urinary incontinence and pain. Treatments can worsen these symptoms. You may one or more the following treatments to manage these symptoms:<\/p>\n\n\n\n As individual factors may affect the suitability of these treatment options, a doctor may recommend watchful waiting or active surveillance. Suitability is particularly important to avoid treatment side effects in some groups of men.\u00a0<\/p>\n\n\n\nWhat is <\/strong>prostate cancer?<\/strong><\/h2>\n\n\n\n
What are the risk factors for prostate cancer?<\/strong><\/h2>\n\n\n\n
TNM staging system<\/h2>\n\n\n\n
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What does stage 3 prostate cancer mean?<\/h2>\n\n\n\n
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What are the symptoms of stage 3 prostate cancer?<\/strong><\/h2>\n\n\n\n
Urinary symptoms:<\/em><\/h3>\n\n\n\n
Sexual problems:<\/em><\/h3>\n\n\n\n
Urinary tract infection:<\/em><\/h3>\n\n\n\n
Diagnosis<\/h2>\n\n\n\n
Prostate<\/em>-specific antigen (PSA) test<\/em><\/h3>\n\n\n\n
Digital rectal examination (DRE)<\/em><\/h3>\n\n\n\n
Magnetic resonance imaging (MRI) scan<\/em><\/h3>\n\n\n\n
Prostate<\/em> biopsy<\/em><\/h3>\n\n\n\n
Computerized tomography (CT) scan<\/em><\/h4>\n\n\n\n
Other tests<\/em><\/h3>\n\n\n\n
Treatment\u00a0<\/strong><\/h2>\n\n\n\n
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Which treatments are suitable for me?<\/h3>\n\n\n\n
Treatment side effects<\/h3>\n\n\n\n
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<\/li>\n\n\n\nTreatment to manage disease and treatment symptoms<\/h3>\n\n\n\n
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<\/li>\n\n\n\nOther treatment options for stage 3 prostate cancer\u00a0<\/h3>\n\n\n\n