{"id":33818,"date":"2022-03-17T07:17:00","date_gmt":"2022-03-17T07:17:00","guid":{"rendered":"https:\/\/www.bensnaturalhealth.com\/blog\/?p=33818"},"modified":"2026-05-30T19:39:07","modified_gmt":"2026-05-30T19:39:07","slug":"psa-doubling-time","status":"publish","type":"post","link":"https:\/\/www.bensnaturalhealth.com\/blog\/prostate-health\/psa-doubling-time\/","title":{"rendered":"Understand PSA Doubling Time"},"content":{"rendered":"Prostate cancer is the most common type of cancer in senior males. In Europe, the incidence is higher than 200 cases per 1000 male population.\n\n<!-- \/wp:post-content -->\n\n<!-- wp:paragraph -->\n\nIt also ranks second as the most common cause of cancer death in males. It is undoubtedly a disease we should address through an early diagnosis and prompt treatment.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nThat is why many studies have focused their attention on prostate cancer screening.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nIn an attempt to detect prostate cancer before it grows very large, doctors started to use the Prostate Specific Antigen (PSA).\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nThe <a href=\"https:\/\/www.bensnaturalhealth.com\/blog\/psa-blood-test\/\" target=\"_blank\" rel=\"noreferrer noopener\">PSA test<\/a> was found to be a good tool to detect cancer in patients without symptoms. But it also bears problems because it sometimes gives positive readings in patients without cancer. Additional tools have been developed in response to PSA failure to provide exact results.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nPSA kinetics was brought in an attempt to see what happens with PSA readings over time. Researchers started to determine cancer risk based on how this value changed through the years. That is why we now have something called PSA velocity.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nBut they also found another PSA value known as PSA doubling time. This one was found to predict cancer aggressiveness. It was also helpful in patients after receiving prostatectomy or radiation therapy.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nBut what is PSA doubling time, and when is this test recommended? You will find the answer to this question and more in the present article.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:heading -->\n<h2 id=\"h-what-is-psa-doubling-time\" class=\"wp-block-heading\"><strong>What is<\/strong> <strong>PSA doubling time?<\/strong><\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n\nBefore understanding PSA doubling time, we should know how serum PSA value behaves over time. It is not like hemoglobin levels which stay the same throughout our lifetime.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nInstead, males are expected to experience a rise in their serum PSA level as they grow older. That is normal and expected in healthy patients, but such an increase should follow a specific pattern.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nPSA velocity measures the rising pattern of PSA levels in each person. Based on these readings, we can get a new PSA after a while and check if the patient follows the same pattern.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nIf they do, a <a href=\"https:\/\/www.bensnaturalhealth.com\/blog\/prostate-cancer\/\" target=\"_blank\" rel=\"noreferrer noopener\">prostate cancer<\/a> diagnosis will be unlikely. Localized prostate cancer may cause a discreet increase in PSA velocity. In most cases, metastatic prostate cancer is preceded by an aggressive rise of these values.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nNow, PSA doubling time is a similar PSA kinetics reading. It measures how much time it takes for PSA to double its value.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nIt has proved useful to predict overall survival and detect aggressive cancer or determine its progression. Moreover, doctors use this measure in patients after <a href=\"https:\/\/www.bensnaturalhealth.com\/blog\/what-happens-to-a-man-when-he-has-his-prostate-removed\/\" target=\"_blank\" rel=\"noreferrer noopener\">prostatectomy<\/a> or <a href=\"https:\/\/www.bensnaturalhealth.com\/blog\/radiation-therapy-for-prostate-cancer\/\" target=\"_blank\" rel=\"noreferrer noopener\">radiation therapy<\/a> to detect biochemical recurrence (1).\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:image {\"id\":33695,\"sizeSlug\":\"full\",\"linkDestination\":\"custom\"} -->\n<figure class=\"wp-block-image size-full\"><\/figure>\n<!-- \/wp:image -->\n\n<!-- wp:heading -->\n<h2 id=\"h-what-can-psa-doubling-time-indicate\" class=\"wp-block-heading\"><strong>What can PSA doubling time indicate?<\/strong><\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n\nUnlike PSA velocity, PSA doubling time is not used as a <a href=\"https:\/\/www.bensnaturalhealth.com\/blog\/age-for-prostate-exam\/\" target=\"_blank\" rel=\"noreferrer noopener\">prostate cancer screening method<\/a>. Instead, it is used in patients already diagnosed or in the process of being diagnosed.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nPSA doubling time is much more specific in these patients, especially if they happen to have a higher tumor grade. But it is also used in patients who have already received treatment for prostate cancer. In each case, it may indicate something different (1):\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:list -->\n<ul>\n \t<li style=\"list-style-type: none;\">\n<ul><!-- wp:list-item -->\n \t<li><strong>In the early stage of prostate cancer diagnosis<\/strong>: Fast PSA doubling time may indicate the possibility of metastasis or advanced prostate cancer. For many cases, the <a href=\"https:\/\/www.bensnaturalhealth.com\/blog\/psa-level-dangerously-high\/\" target=\"_blank\" rel=\"noreferrer noopener\">rapid PSA increase<\/a> rate is correlated with the Gleason score (2). Thus, even if the measurement is not commonly used before treatment, <a href=\"https:\/\/sciendo.com\/article\/10.2478\/prolas-2021-0047\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">new studies<\/a> suggest a possible role in these patients, too (1).<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<ul>\n \t<li style=\"list-style-type: none;\">\n<ul>\n \t<li><strong>In prostate cancer follow-up<\/strong>: In patients with ongoing cancer, fast PSA doubling time may indicate progression to metastatic disease (2).<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<ul>\n \t<li style=\"list-style-type: none;\">\n<ul>\n \t<li><strong>After prostate cancer treatment, rapid PSA doubling time indicates biochemical recurrence survival after radical prostatectomy or radiation therapy<\/strong>. These patients may not have physical signs of prostate cancer aggressiveness. But they have a biochemical progression of prostate cancer, which is detected in serum PSA (3).<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<!-- \/wp:list-item -->\n\n<!-- \/wp:list -->\n\n<!-- wp:paragraph -->\n\nStill, it is essential to note that some studies report contradictory results. Some of them demonstrate no correlation between fast PSA doubling time and the histological stage of prostate cancer.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nBut we\u2019re dealing with clinical oncology, which is very complex and highly variable in different populations. Thus, although still imperfect, it is a tool that has helped in the past to make accurate predictions (1).\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:heading -->\n<h2 id=\"h-reasons-for-a-fast-psa-doubling-time\" class=\"wp-block-heading\"><strong>Reasons for a fast PSA doubling time<\/strong><\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n\nWhy would your PSA level double after radical prostatectomy? The reasons vary for each patient. For example, you may not have a visible tumor, but PSA doubling time will be very fast in metastatic disease. Also, <a href=\"https:\/\/www.bensnaturalhealth.com\/blog\/what-to-expect-after-radiation\/\" target=\"_blank\" rel=\"noreferrer noopener\">after radiation therapy<\/a>, your tumor may still display progression towards metastasis.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nIn the early stage of diagnosis, the main reasons for fast PSA doubling time include:\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:list -->\n<ul>\n \t<li style=\"list-style-type: none;\">\n<ul><!-- wp:list-item -->\n \t<li>Aggressive disease<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<ul>\n \t<li style=\"list-style-type: none;\">\n<ul>\n \t<li>High Gleason score<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<ul>\n \t<li style=\"list-style-type: none;\">\n<ul>\n \t<li>Metastasis<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<!-- \/wp:list-item -->\n\n<!-- \/wp:list -->\n\n<!-- wp:paragraph -->\n\nRemember that prostate cancer cells create PSA, too. The tissue divides rapidly and continues releasing this blood marker. Local inflammation increases blood vessel contact with the tumor, and PSA leakage to the bloodstream rises. All of these factors influence PSA doubling time in prostate cancer.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:heading -->\n<h2 id=\"h-what-is-a-normal-psa-doubling-time\" class=\"wp-block-heading\"><strong>What is a normal PSA doubling time?<\/strong><\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n\nThere is not a single PSA doubling time reading considered safe. Instead, PSA doubling time works within ranges, and each is associated with a given prognosis. For instance (4):\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:list -->\n<ul>\n \t<li style=\"list-style-type: none;\">\n<ul><!-- wp:list-item -->\n \t<li>PSA doubling time equal to or lower than 12 months is associated with a 50% chance of death within five years of biochemical relapse.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<ul>\n \t<li style=\"list-style-type: none;\">\n<ul>\n \t<li>PSA doubling time higher than 12 months is associated with a 10% chance of death within five years of biochemical relapse.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<!-- \/wp:list-item -->\n\n<!-- \/wp:list -->\n\n<!-- wp:paragraph -->\n\nSome authors have also proposed a more complex association that considers PSA doubling time coupled with the <a href=\"https:\/\/www.bensnaturalhealth.com\/blog\/prostate-cancer-gleason-score\/\" target=\"_blank\" rel=\"noreferrer noopener\">Gleason score<\/a>. They found that PSA doubling time was handy to predict progression to metastasis in patients with a Gleason score lower than 8.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:heading -->\n<h2 id=\"h-natural-ways-to-reduce-psa-doubling-time\" class=\"wp-block-heading\"><strong>Natural ways to reduce PSA doubling time<\/strong><\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n\nInitially, prostate cancer treatment and follow-up are important to reduce PSA doubling time.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nAfter following a treatment course, you can also try natural methods. All methods to reduce your PSA level are also helpful to reduce PSA doubling time. For instance:\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:heading {\"level\":3} -->\n<h3 id=\"h-1-follow-a-healthy-diet\" class=\"wp-block-heading\"><strong>1. Follow a healthy diet<\/strong><\/h3>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n\nRemember that some foods have a higher inflammatory profile than others. PSA values increase in the presence of inflammation. So, it is recommended to stay away from saturated fats and irritants of the urinary tract.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:heading {\"level\":3} -->\n<h3 id=\"h-2-exercise-regularly\" class=\"wp-block-heading\"><strong>2. Exercise regularly<\/strong><\/h3>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n\nEach case is different, and some patients feel fatigued and have a low tolerance to exercise. But the more active you are, the more likely it is to increase the survival rate. Your PSA level is more likely to stay in control, too.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:heading {\"level\":3} -->\n<h3 id=\"h-3-manage-your-stress-levels\" class=\"wp-block-heading\"><strong>3. Manage your stress levels<\/strong><\/h3>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n\nBelieve it or not, PSA may also increase if you don\u2019t know how to cope with stress. Different relaxation methods such as yoga and meditation may modulate prostate cancer outcomes. They could even keep PSA scores under control in some cases.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:heading {\"level\":3} -->\n<h3 id=\"h-4-antioxidant-foods-and-supplements\" class=\"wp-block-heading\"><strong>4. Antioxidant foods and supplements<\/strong><\/h3>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n\nFree radicals contribute to the inflammation and the destruction of healthy prostate tissue. Thus, consuming <a href=\"https:\/\/www.bensnaturalhealth.com\/blog\/general-health\/antioxidant-foods\/\" target=\"_blank\" rel=\"noreferrer noopener\">antioxidant foods<\/a> is essential to keep inflammation and PSA levels at bay.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nA standard recommendation for these patients is <a href=\"https:\/\/www.bensnaturalhealth.com\/blog\/green-tea-prostate\/\" target=\"_blank\" rel=\"noreferrer noopener\">green tea<\/a>. It is known to modulate prostate cancer by taking care of hormonal imbalances and protecting the gland against free radical damage. Other anti-inflammatory foods, herbs, and <a href=\"https:\/\/www.bensnaturalhealth.com\/blog\/supplements-to-lower-psa-levels\/\" target=\"_blank\" rel=\"noreferrer noopener\">supplements<\/a> can also do the trick.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:heading -->\n<h2 id=\"h-conclusion\" class=\"wp-block-heading\"><strong>Conclusion<\/strong><\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n\nPSA doubling time is mainly useful for prostate cancer patients who underwent treatment. After treatment, it gives doctors a prognosis of aggressiveness.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nPSA doubling time lower than 12 months is associated with a higher chance of cancer-related death. Studies also show that a fast doubling time may predict the risk of\u00a0metastasis.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nYou can keep your PSA level under control through a healthy lifestyle and using anti-inflammatory and antioxidant foods and herbs.\n\n<!-- \/wp:paragraph -->","protected":false},"excerpt":{"rendered":"<p>Prostate cancer is the most common type of cancer in senior males. In Europe, the incidence is higher than 200 cases per 1000 male population. It also ranks second as the most common cause of cancer death in males. It is undoubtedly a disease we should address through an early diagnosis and prompt treatment. That [&hellip;]<\/p>\n","protected":false},"author":13,"featured_media":33820,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[1],"tags":[20],"health_topic":[124,135],"class_list":["post-33818","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog","tag-prostate-cancer","health_topic-prostate-health","health_topic-psa"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.2 (Yoast SEO v27.5) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>PSA Doubling Time: What Is It &amp; How Can You Reduce It?<\/title>\n<meta name=\"description\" content=\"Read this blog to learn what PSA doubling time is, what it can indicate, and some natural ways to reduce your PSA doubling time.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, 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