{"id":35847,"date":"2022-07-06T05:55:00","date_gmt":"2022-07-06T05:55:00","guid":{"rendered":"https:\/\/www.bensnaturalhealth.com\/blog\/?post_type=diabeteshealth&#038;p=35847"},"modified":"2026-04-05T07:56:02","modified_gmt":"2026-04-05T07:56:02","slug":"metformin-overdose","status":"publish","type":"post","link":"https:\/\/www.bensnaturalhealth.com\/blog\/diabetes-health\/metformin-overdose\/","title":{"rendered":"Metformin Overdosage: Consequences and What to do"},"content":{"rendered":"\n<p><a href=\"https:\/\/blog.bensnaturalhealth.com\/diabetes-health\/metformin\/\" target=\"_blank\" rel=\"noreferrer noopener\">Metformin<\/a> is one of the most commonly prescribed medications for type 2 diabetes.<\/p>\n\n\n\n<p>Metformin is in a drug class called biguanides. Biguanides help reduce the amount of sugar your liver makes while <a href=\"https:\/\/blog.bensnaturalhealth.com\/diabetes-health\/boost-insulin-sensitivity\/\" target=\"_blank\" rel=\"noreferrer noopener\">improving insulin sensitivity<\/a>, which helps reduce high blood sugar.\u00a0<\/p>\n\n\n\n<p>Like any prescription drug, it\u2019s possible to get too much of the medication in your system, which can be harmful and even fatal.&nbsp;<\/p>\n\n\n\n<p>Here\u2019s what you need to know about overdosing on metformin.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-dosage\">Metformin Maximum Daily Intake<\/h2>\n\n\n\n<p>The common dosage for metformin ranges from 500 milligrams to a maximum of 2,550 milligrams per day. It\u2019s usually in pill form and recommended to split the dose among meals, typically three times per day.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-types-of-metformin\">Types of Metformin<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Regular<\/li>\n\n\n\n<li>Extended-release (XR). Extended-release metformin can be taken just once a day.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-how-much-metformin-is-an-overdose\">How much metformin is an overdose?<\/h3>\n\n\n\n<p>There is no standard for what constitutes a metformin overdose. In general, a medication overdose occurs when you take more medication than is prescribed in a given time. Overdoses can be an accident or intentional, such as suicide attempts.<\/p>\n\n\n\n<p>Accidentally taking an extra 1-2 tablets of metformin one time likely won\u2019t cause any harm, so you probably don\u2019t have to worry about rare slip-ups when you take an extra dose. However, doubling your prescribed dose for a prolonged period may increase your risk of medication toxicity.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"217\" src=\"https:\/\/blog.bensnaturalhealth.com\/wp-content\/uploads\/2021\/11\/metformin-side-effects-1-1024x217.jpg\" alt=\"metformin side effects\" class=\"wp-image-31855\" srcset=\"https:\/\/www.bensnaturalhealth.com\/blog\/wp-content\/uploads\/2021\/11\/metformin-side-effects-1-1024x217.jpg 1024w, https:\/\/www.bensnaturalhealth.com\/blog\/wp-content\/uploads\/2021\/11\/metformin-side-effects-1-300x64.jpg 300w, https:\/\/www.bensnaturalhealth.com\/blog\/wp-content\/uploads\/2021\/11\/metformin-side-effects-1-768x163.jpg 768w, https:\/\/www.bensnaturalhealth.com\/blog\/wp-content\/uploads\/2021\/11\/metformin-side-effects-1.jpg 1180w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-symptoms\">Common Symptoms of Metformin Overdose<\/h2>\n\n\n\n<p>Based on case studies of metformin overdoses, the most common symptoms of a metformin overdose include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Nausea<\/li>\n\n\n\n<li>Vomiting<\/li>\n\n\n\n<li>Diarrhea<\/li>\n\n\n\n<li>Epigastric pain<\/li>\n\n\n\n<li>Increased thirst<\/li>\n\n\n\n<li>Reduced appetite<\/li>\n\n\n\n<li>Lethargy<\/li>\n\n\n\n<li>Increased breathing rate<\/li>\n\n\n\n<li>Hypotension (low blood pressure)<\/li>\n\n\n\n<li>Hypothermia<\/li>\n\n\n\n<li>Acute renal failure<\/li>\n\n\n\n<li>Coma<\/li>\n\n\n\n<li>Cardiac arrest&nbsp;<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-side-effects\">Overdose on Metformin Side Effects<\/h2>\n\n\n\n<p>Metformin comes in tablet form and usually involves taking several tablets each day. Taking medications comes with a risk of overdose, such as accidentally taking more tablets than you\u2019re prescribed. Drug overdoses can be accidental or intentional &#8211; intentional drug overdoses are usually part of a suicide attempt.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-what-happens-to-your-body-if-you-overdose-on-metformin\">What happens to your body if you overdose on metformin?<\/h3>\n\n\n\n<p>Metformin is cleared from your body by your kidneys. If you have excessive amounts of metformin in your system from an overdose, then your kidneys won\u2019t be able to clear the medication from your system.<\/p>\n\n\n\n<p>A medication overdose can damage your kidneys. If your kidneys aren\u2019t working correctly, this can impact other aspects of your health since your kidneys also play a large role in regulating your blood pressure, among many other functions.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-serious-conditions\">Serious Conditions<\/h3>\n\n\n\n<p>If you develop lactic acidosis, you\u2019ll go into a state called metabolic acidosis. Metabolic acidosis is when your body\u2019s pH level rises too much from the extra acid in your body. Metabolic acidosis is worsened when your kidneys can\u2019t clear the excess acid from your system, which might happen if you have an acute (short-term) kidney injury from a metformin overdose.<\/p>\n\n\n\n<p>Another case of (intentional) metformin overdose was in a 16-year-old girl who ingested 30-35 850 milligram metformin tablets (at least 25,500 milligrams). After being hospitalized for 48 hours, the patient died from multi-organ failure (<a href=\"https:\/\/theijcp.org\/index.php\/ijcp\/article\/view\/259\/210\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">2<\/a>).<\/p>\n\n\n\n<p>It\u2019s estimated that 30-50% of metformin overdoses are fatal, but that number can be even higher if you\u2019re already medically fragile, such as having kidney problems or being older in age. Cases of intentional overdoses, which was the case for the previous two examples, come with a higher mortality risk.<\/p>\n\n\n\n<p>Metformin overdoses cause lactic acidosis, which is apparent in all documented cases of metformin overdoses. Another type of biguanide medication (the drug class metformin is in) called phenformin was recalled by the FDA in the 1970s because of a high rate of severe lactic acidosis.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"217\" src=\"https:\/\/blog.bensnaturalhealth.com\/wp-content\/uploads\/2022\/04\/metformin-1-1024x217.jpg\" alt=\"metformin birth defects\" class=\"wp-image-34881\" srcset=\"https:\/\/www.bensnaturalhealth.com\/blog\/wp-content\/uploads\/2022\/04\/metformin-1-1024x217.jpg 1024w, https:\/\/www.bensnaturalhealth.com\/blog\/wp-content\/uploads\/2022\/04\/metformin-1-300x64.jpg 300w, https:\/\/www.bensnaturalhealth.com\/blog\/wp-content\/uploads\/2022\/04\/metformin-1-768x163.jpg 768w, https:\/\/www.bensnaturalhealth.com\/blog\/wp-content\/uploads\/2022\/04\/metformin-1.jpg 1180w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-lactic-acidosis\">Metformin Overdose Risks: lactic Acidosis\u00a0<\/h2>\n\n\n\n<p>The main risk from overdosing on metformin is lactic acidosis. <a href=\"https:\/\/blog.bensnaturalhealth.com\/diabetes-health\/metformin-and-lactic-acidosis\/\" target=\"_blank\" rel=\"noreferrer noopener\">Lactic acidosis<\/a> is a serious condition where your body creates more lactic acid than your body can clear.&nbsp;<\/p>\n\n\n\n<p>The <a href=\"https:\/\/blog.bensnaturalhealth.com\/diabetes-health\/lactic-acidosis-symptoms\/\" target=\"_blank\" rel=\"noreferrer noopener\">symptoms of lactic acidosis<\/a> usually set in quickly and include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Abdominal or stomach discomfort<\/li>\n\n\n\n<li>Decreased appetite<\/li>\n\n\n\n<li>Diarrhea<\/li>\n\n\n\n<li>Fast, shallow breathing<\/li>\n\n\n\n<li>Discomfort<\/li>\n\n\n\n<li>Muscle pain or cramping<\/li>\n\n\n\n<li>Unusual sleepiness, tiredness, or weakness<\/li>\n<\/ul>\n\n\n\n<p>Lactic acidosis is very rare when metformin is taken as prescribed. According to a position statement in the American Diabetes Association\u2019s <em>Diabetes Care, <\/em>\u201cWhen metformin is used as labeled, the increased risk of lactic acidosis is either zero or so close to zero that it cannot be factored into ordinary clinical decision making.\u201d (<a href=\"https:\/\/diabetesjournals.org\/care\/article\/27\/7\/1791\/24524\/\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">3<\/a>)<\/p>\n\n\n\n<p>In one case, a 29-year-old man took over 60 grams of metformin, the equivalent of 60,000 milligrams (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2672258\/\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">1<\/a>). For perspective, the maximum daily dose of metformin is 2,550 milligrams. That patient suffered severe <a href=\"https:\/\/blog.bensnaturalhealth.com\/diabetes-health\/lactic-acidosis\/\" target=\"_blank\" rel=\"noreferrer noopener\">lactic acidosis<\/a> and died a little over a day later.<\/p>\n\n\n\n<p>If you have severe renal impairment or <a href=\"https:\/\/blog.bensnaturalhealth.com\/diabetes-health\/diabetic-kidney-disease\/\" target=\"_blank\" rel=\"noreferrer noopener\">kidney disease<\/a>, you might also be at greater risk of developing lactic acidosis because your kidneys can\u2019t clear the lactic acid from your system.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-what-to-do-if-one-has-overdosed-on-metformin\">What to do if one has overdosed on metformin<\/h2>\n\n\n\n<p>The maximum daily dose of metformin is 2550 mg.\u00a0If you think you\u2019ve overdosed on metformin, you should contact the Poison Control Centers at (800) 222-1222. Seek emergency medical care if symptoms of an overdose are being shown. If you or the person you know becomes unconscious, you should call 911 immediately.<\/p>\n\n\n\n<p>The sooner you seek medical care; the more favorable your outcomes will likely be.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-treatment-for-a-metformin-overdose\">Treatment for a metformin overdose<\/h2>\n\n\n\n<p>If you seek medical attention for a potential metformin overdose, you\u2019ll likely have several blood tests, such as blood glucose, serum lactate level, pH, anion gap, electrolytes, and more.&nbsp;<\/p>\n\n\n\n<p>The treatment for a metformin overdose will depend on the severity and symptoms presented. For lactic acidosis, intravenous sodium bicarbonate is the main treatment. If a metformin overdose impacted your kidneys, you might receive dialysis until your kidneys recover.&nbsp;<\/p>\n\n\n\n<p>For more minor cases, you might be observed in a hospital setting to ensure your vital signs and blood tests are stable before you\u2019re sent home.<\/p>\n\n\n\n<p>In some cases, a metformin overdose may be treated with methylene blue. In one case, methylene blue was used as a last line of therapy in a case of an intentional metformin overdose (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26150642\/\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">4<\/a>). The individual who was in severe shock and had metabolic acidosis ended up recovering with no long-term consequences.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"250\" src=\"https:\/\/blog.bensnaturalhealth.com\/wp-content\/uploads\/2020\/03\/large-blood-test-blog-header-image-1.jpg\" alt=\"blood test\" class=\"wp-image-20700\" srcset=\"https:\/\/www.bensnaturalhealth.com\/blog\/wp-content\/uploads\/2020\/03\/large-blood-test-blog-header-image-1.jpg 1000w, https:\/\/www.bensnaturalhealth.com\/blog\/wp-content\/uploads\/2020\/03\/large-blood-test-blog-header-image-1-300x75.jpg 300w, https:\/\/www.bensnaturalhealth.com\/blog\/wp-content\/uploads\/2020\/03\/large-blood-test-blog-header-image-1-768x192.jpg 768w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-are-there-any-long-term-effects-after-overdosing-on-metformin\">Are there any long-term effects after overdosing on metformin?<\/h2>\n\n\n\n<p>If your metformin overdose is minor, you\u2019ll likely have no long-term effects. The risk of long-term consequences is higher for severe cases of metformin overdose, such as intentional overdoses. You might suffer from kidney or heart problems after a severe metformin overdose, among other potential issues.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-conclusion\">Conclusion<\/h2>\n\n\n\n<p>Metformin overdose is possible but is considered rare overall. The most serious and fatal metformin overdose cases occured with intentional overdoses in suicide attempts. In some cases, the doses were 30,000 milligrams and higher, compared to a typical maximum dose of 2,550 milligrams.<\/p>\n\n\n\n<p>Taking an extra metformin tablet or two on occasion will likely bear no ill effects. If you think you\u2019ve overdosed on metformin, contact the Poison Control Centers for guidance on whether you should seek emergency medical care.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-explore-more\">Explore More<\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/blog.bensnaturalhealth.com\/diabetes-health\/lactic-acidosis-symptoms\/\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"217\" src=\"https:\/\/blog.bensnaturalhealth.com\/wp-content\/uploads\/2021\/12\/lactic-acidosis-symptoms-1024x217.jpeg\" alt=\"lactic acidosis symptoms\" class=\"wp-image-32555\" srcset=\"https:\/\/www.bensnaturalhealth.com\/blog\/wp-content\/uploads\/2021\/12\/lactic-acidosis-symptoms-1024x217.jpeg 1024w, https:\/\/www.bensnaturalhealth.com\/blog\/wp-content\/uploads\/2021\/12\/lactic-acidosis-symptoms-300x64.jpeg 300w, https:\/\/www.bensnaturalhealth.com\/blog\/wp-content\/uploads\/2021\/12\/lactic-acidosis-symptoms-768x163.jpeg 768w, https:\/\/www.bensnaturalhealth.com\/blog\/wp-content\/uploads\/2021\/12\/lactic-acidosis-symptoms.jpeg 1180w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure>\n\n\n\n<p><a href=\"https:\/\/blog.bensnaturalhealth.com\/diabetes-health\/lactic-acidosis-symptoms\/\" target=\"_blank\" rel=\"noreferrer noopener\">10 Symptoms Of Lactic Acidosis<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Metformin is one of the most commonly prescribed medications for type 2 diabetes. Metformin is in a drug class called biguanides. Biguanides help reduce the amount of sugar your liver makes while improving insulin sensitivity, which helps reduce high blood sugar.\u00a0 Like any prescription drug, it\u2019s possible to get too much of the medication in [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":35848,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[1],"tags":[],"health_topic":[125,145],"class_list":["post-35847","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog","health_topic-diabetes-health","health_topic-diabetes-medication"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.2 (Yoast SEO v27.5) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Metformin Overdosage: Consequences and What to do - Ben&#039;s Natural Health<\/title>\n<meta name=\"description\" content=\"Learn about what a metformin overdose is, what signs and symptoms you should look for, and how to treat an overdose if it occurs.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.bensnaturalhealth.com\/blog\/diabetes-health\/metformin-overdose\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Metformin Overdosage: Consequences and What to do\" \/>\n<meta property=\"og:description\" content=\"Learn about what a metformin overdose is, what signs and symptoms you should look for, and how to treat an overdose if it occurs.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.bensnaturalhealth.com\/blog\/diabetes-health\/metformin-overdose\/\" \/>\n<meta property=\"og:site_name\" content=\"Ben&#039;s Natural Health\" \/>\n<meta property=\"article:published_time\" content=\"2022-07-06T05:55:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-05T07:56:02+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.bensnaturalhealth.com\/blog\/wp-content\/uploads\/2022\/06\/Can-you-overdose-on-metformin-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1600\" \/>\n\t<meta property=\"og:image:height\" content=\"400\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Diana Gariglio-Clelland\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Diana Gariglio-Clelland\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":[\"WebPage\",\"MedicalWebPage\"],\"@id\":\"https:\\\/\\\/www.bensnaturalhealth.com\\\/blog\\\/diabetes-health\\\/metformin-overdose\\\/\",\"url\":\"https:\\\/\\\/www.bensnaturalhealth.com\\\/blog\\\/diabetes-health\\\/metformin-overdose\\\/\",\"name\":\"Metformin Overdosage: Consequences and What to do - 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