{"id":36510,"date":"2022-08-14T05:49:00","date_gmt":"2022-08-14T05:49:00","guid":{"rendered":"https:\/\/www.bensnaturalhealth.com\/blog\/?post_type=sexualhealth&p=36510"},"modified":"2026-04-05T08:23:33","modified_gmt":"2026-04-05T08:23:33","slug":"drugs-not-to-take-with-viagra","status":"publish","type":"post","link":"https:\/\/www.bensnaturalhealth.com\/blog\/hormone-health\/drugs-not-to-take-with-viagra\/","title":{"rendered":"10 Drugs To Avoid When You Take Viagra"},"content":{"rendered":"\n

Viagra is safe for most people, but that is not true for all. <\/p>\n\n\n\n

That\u2019s why you can\u2019t find viagra on the shelf with over-the-counter drugs. <\/p>\n\n\n\n

You need a prescription because it has interactions with several medications. <\/p>\n\n\n\n

Also, your doctor needs to evaluate sildenafil contraindication before prescribing this drug.<\/p>\n\n\n\n

But what are the dangers of viagra for people who take multiple drugs? Who shouldn\u2019t take viagra? <\/p>\n\n\n\n

In this article, you will find the main ingredient in viagra and what drugs you should not take with this medication.<\/p>\n\n\n\n

What is Viagra?<\/strong><\/h2>\n\n\n\n

Viagra<\/a> is the most famous drug for erectile dysfunction. It belongs to a family of medications called phosphodiesterase type 5 inhibitors. They increase the blood flow to the penis structures, facilitating erections and intercourse.<\/p>\n\n\n\n

The ingredient in viagra is known as sildenafil, and it is not the only PDE5 inhibitor in existence. We also have others, such as tadalafil<\/a>, vardenafil, and avanafil. <\/p>\n\n\n\n

The drug does not increase the sensitivity of the penis. But it facilitates erections and gives a little push to those who need it.<\/p>\n\n\n\n

How does Viagra work?<\/strong><\/h2>\n\n\n\n

You could say that nitric oxide and viagra work together to prompt and maintain an erection. Initially, and as a result of sexual stimulation, nitric oxide is released in the corpus cavernosum. <\/p>\n\n\n\n

One of the key benefits of nitric oxide sexually<\/a> is that it helps the body increase blood flow<\/a>. Then, a substance known as cGMP is also released, causing muscle relaxation in the erectile tissue. When the muscle is relaxed, the blood flow can freely access the corpora cavernosa. That\u2019s how a normal erection happens.<\/p>\n\n\n\n

After sex, it is also normal that cGMP gets destroyed by an enzyme known as PDE5. However, men with erectile dysfunction have too much PDE5. <\/p>\n\n\n\n

It activates before due time, and men can\u2019t achieve an erection. That\u2019s when viagra can help. It inhibits PDE5 and helps you achieve an erection.<\/p>\n\n\n\n

However, the enzyme PDE5 is not only found in the erectile tissue. That\u2019s why doctors have very specific viagra prescribing information for patients. <\/p>\n\n\n\n

It also has an interaction with other drugs. Thus, the side effects of viagra<\/a> in older men depend on their health problems and current medications.<\/p>\n\n\n\n

For instance, one of the side effects of sildenafil<\/a> is hypotension<\/a>. It causes a slight blood pressure change, which is why it is useful in pulmonary arterial hypertension. But it won\u2019t be noticeable unless you have a hypotensive problem or use other hypotensive drugs.\u00a0<\/p>\n\n\n\n

Another side effect is nasal congestion due to increased blood flow in the nasal cavity (1).<\/p>\n\n\n\n

\"natural<\/a><\/figure>\n\n\n\n

10 drugs you should not take with Viagra<\/strong><\/h2>\n\n\n\n

Sildenafil by itself won\u2019t likely cause problems in healthy individuals. When side effects happen, it is usually due to a baseline health problem or drug interactions. <\/p>\n\n\n\n

Co-administration of these drugs with viagra can have a consequence. Below we share which drugs you should not take with Viagra. <\/p>\n\n\n\n

1) Nitrate medications<\/strong><\/h3>\n\n\n\n

Medicines with nitrates are probably the most dangerous interaction of viagra. Examples of nitrates are isosorbide mononitrate, isosorbide dinitrate, and nitroglycerin. <\/p>\n\n\n\n

Using viagra and nitroglycerin in combination can cause an excessive dilatation of the blood vessels. The blood pressure drops dramatically, and the patient can experience a stroke, heart attack, or another cardiovascular event (2).<\/p>\n\n\n\n

2) Mifepristone<\/strong><\/h3>\n\n\n\n

This is also popularly known as the abortion pill. But why would a man take this type of medication? It happens to be useful for men with Cushing syndrome. <\/p>\n\n\n\n

But concomitant use of mifepristone and viagra can be dangerous. The drug slows down the removal of viagra. The drug stays in your system and can cause serious adverse events.<\/p>\n\n\n\n

3-4) Riociguat and Vericiguat<\/strong><\/h3>\n\n\n\n

Viagra started as a drug to treat pulmonary hypertension, but they found that erections as a side effect were more pronounced than its current aim. <\/p>\n\n\n\n

Riociguat and vericiguat work similarly, but they are designed for primary pulmonary hypertension and heart failure, respectively. <\/p>\n\n\n\n

Patients taking this drug and viagra simultaneously will have double effects and excessive dilatation of the blood vessels. It happens similar to what we discussed about nitrates medication use (3<\/a>).<\/p>\n\n\n\n

5-6) Lefamulin and Voxelotor<\/strong><\/h3>\n\n\n\n

These drugs are used as antibiotics and as a treatment for sickle cell disease, respectively. But they share a common contraindication with viagra. <\/p>\n\n\n\n

They both slow down the removal of Viagra. They do so to a lesser degree than mifepristone, but you should not overlook the interaction.<\/p>\n\n\n\n

7) Poppers<\/strong><\/h3>\n\n\n\n

This is a recreational drug commonly used to enhance sexual sensation. That\u2019s why many people wonder if you can use poppers and viagra together. <\/p>\n\n\n\n

The answer is no because poppers can include different nitrates and cause the same blood vessel dilatation and cardiovascular risk as nitroglycerine. <\/p>\n\n\n\n

You will also be at a higher risk of sexually transmitted diseases after using viagra and poppers (4).<\/p>\n\n\n\n

8) Anti-hypertensives and benign prostatic hyperplasia medications<\/strong><\/h3>\n\n\n\n

This interaction is not as bad as the ones listed above but is still worth noting. <\/p>\n\n\n\n

Alpha-blocker therapy can induce hypotension when taken together with viagra. The interaction depends on the alpha-blocker dose and your own baseline blood pressure levels. <\/p>\n\n\n\n

Thus, talk to your doctor before using viagra if you use drugs such as doxazosin<\/a>, terazosin<\/a>, and tamsulosin<\/a>. They are commonly used for benign prostatic hyperplasia.<\/p>\n\n\n\n

9) Protease inhibitor therapies<\/strong><\/h3>\n\n\n\n

These drugs inhibit a liver enzyme that breaks down viagra. It interacts with how the liver processes viagra. Thus, these inhibitors will potentially cause other side effects associated with viagra.<\/p>\n\n\n\n

10) Other medications<\/strong><\/h3>\n\n\n\n

Other medications can interfere with viagra processing\u2014for example, itraconazole and erythromycin. Thus, if you are taking meds or starting a new treatment, always talk about this to your doctor to ensure no interactions are expected.<\/p>\n\n\n\n

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What interferes with Viagra working?<\/strong><\/h2>\n\n\n\n

Two main things interfere with Viagra working. They are (5):<\/p>\n\n\n\n