Effectiveness of Trulicity<\/h3>\n\n\n\n
A 40-week clinical trial assessed the effectiveness of Trulicity compared to another diabetes medication (Ozempic). 1201 patients with type 2 diabetes who were at least 18 years old were included in the study. The participant’s A1cs ranged from 7-10.5%.<\/p>\n\n\n\n
The group receiving 0.75 milligrams weekly of Trulicity reduced their A1c by an average of 1.1% compared to their baseline. The participants receiving 1.5 milligrams of Trulicity lowered their A1c by an average of 1.3%.<\/p>\n\n\n\n
Another study<\/a> looked at Trulicity\u2019s ability to lower blood sugar. The average reduction in hemoglobin A1c was 1.2% taking 1.5 milligrams weekly and 1.4% taking 3 milligrams weekly (over 18 weeks).<\/p>\n\n\n\n Trulicity can also promote modest weight loss. Studies on Trulicity weight loss results<\/a> found an average weight loss of around 4.6 pounds taking .75 milligrams weekly.<\/p>\n\n\n\n There are potential side effects and risks that come with taking Trulicity. While some side effects are minor, there are risks for more serious health issues.<\/p>\n\n\n\n The most common side effects you may experience with Trulicity are:<\/p>\n\n\n\n More rarely, Trulicity may increase your risk of more severe health problems like:<\/p>\n\n\n\n Trulicity and other GLP-1 receptor agonists have caused thyroid cancer in rodents. There is a chance that Trulicity could increase your risk of thyroid cancer, but the risk isn\u2019t quite clear in humans since the dose used in rodents was much higher than a typical human dose.<\/p>\n\n\n\n You shouldn\u2019t take Trulicity or other GLP-1 receptor agonists if you have a history of thyroid cancer or a thyroid tumor. If anyone in your family has a history of medullary thyroid carcinoma, a type of thyroid cancer, you also shouldn’t take Trulicity.<\/p>\n\n\n\n You should also avoid taking Trulicity if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN2), a rare disorder that causes tumors to form on glands such as your thyroid.<\/p>\n\n\n\n If you experience any of these symptoms while taking Trulicity, you should alert your healthcare provider immediately:<\/p>\n\n\n\n According to a case study<\/a>, Trulicity may cause pancreatitis, a painful inflammation of your pancreas. You shouldn\u2019t take Trulicity or other GLP-1 receptor agonists if you have a history of pancreatitis.<\/p>\n\n\n\n If you experience any of these symptoms of pancreatitis<\/a> while taking Trulicity, you should let your healthcare provider know right away:<\/p>\n\n\n\n <\/p>\n\n\n\n Due to the side effects of Trulicity, some people look for alternatives to treat their diabetes. Below, we discuss 15 Trulicity alternatives.<\/p>\n\n\n\n Ozempic is a brand name for an injectable form of semaglutide. The FDA approved ozempic in 2017. The typical dose of Ozempic is between 0.5-2 milligrams weekly.<\/p>\n\n\n\n According to studies, Ozempic lowered the average A1c of 8% by around 1 -1.5% over 30-56 weeks. In addition, participants of studies lost as much as 15-18% of their starting body weights while taking the maximum weekly dose of Ozempic.<\/p>\n\n\n\n Losing weight often improves glycemic control, which is why this weight loss from Ozempic<\/a> is considered significant. Ozempic isn\u2019t approved as a weight loss drug, though.<\/p>\n\n\n\n According to some clinical studies, Ozempic lowered A1c<\/a> and caused greater weight loss than Trulicity and Bydureon (another GLP-1 receptor agonist).<\/p>\n\n\n\n When comparing Trulicity vs Ozempic<\/a>, Ozempic is more likely to cause retinopathy and vision changes than Trulicity, which is one potential advantage Trulicity has over Ozempic.<\/p>\n\n\n\n The main difference between Trulicity vs Rybelsus<\/a> is that Trulicity is an injectable medication, and Rybelsus is oral. Rybelsus is an oral form of the drug semaglutide, a GLP-1 receptor agonist. Unlike Trulicity, Rybelsus is taken daily, not weekly. <\/p>\n\n\n\n The United States FDA approved Rybelsus in 2019 to treat type 2 diabetes. Rybelsus comes in 3-, 7-, and 14-milligram tablets, with a typical dosing range between 7 and 14 milligrams daily. It\u2019s currently the only oral GLP-1 receptor agonist on the market.<\/p>\n\n\n\n One study<\/a> noted that Rybelsus is just as effective as injectable forms of semaglutide. According to studies, Rybelsus lowered hemoglobin A1c<\/a> levels by over 1% over a six-month period (average starting A1c was 8%).<\/p>\n\n\n\n Bydureon BCise<\/a> is the brand name for exenatide, yet another GLP-1 receptor agonist. This is a weekly injectable medication to treat type 2 diabetes, with a recommended dose of 2 milligrams every 7 days (weekly).<\/p>\n\n\n\n In two clinical studies lasting 28 weeks in adults with type 2 diabetes, Bydureon BCise<\/a> lowered A1C levels by an average of 1.1% and 1.4% (average starting A1cs were 8.4% and 8.5%, respectively.\u00a0<\/p>\n\n\n\n When comparing Trulicity vs Bydureon, Bydureon doesn\u2019t seem to promote as much weight loss as Trulicity, with average weight loss averaging three pounds (1.4 kilograms).<\/p>\n\n\n\n Victoza is the brand name for liraglutide, another GLP-1 receptor agonist. The Food and Drug Administration (FDA) approved Victoza<\/a> in 2010 for use in people with type 2 diabetes who are ten years of age and older. <\/p>\n\n\n\n One difference between Trulicity vs Victoza is that Victoza is a once-daily injectable medication, whereas Trulicity is weekly. Typical doses of Victoza are 1.2 and 1.8 milligrams.<\/p>\n\n\n\n According to a 52-week study<\/a>, Victoza reduced participants\u2019 A1cs (mean baseline value of 8.2%) by 0.84% with a dose of 1.2 milligrams and by 1.14% with a dose of 1.8 milligrams.<\/p>\n\n\n\n A review<\/a> of 13 randomized controlled trials was done in 2011, showing that Victoza lowered hemoglobin A1c values by 0.84%-1.5%, which is around the typical range for Trulicity. <\/p>\n\n\n\n In addition, Victoza promoted a 34% to 118% increase in insulin release, which is the primary way it acts to lower blood glucose levels.<\/p>\n\n\n\n Next, we\u2019ll discuss Trulicity vs metformin<\/a>. Metformin is considered a first-line therapy for type 2 diabetes and has been used frequently since the FDA approved it in 1994.<\/p>\n\n\n\n Metformin is in a drug class called biguanides, so it works differently than Trulicity and other GLP-1 receptor agonists. Biguanides help reduce the amount of sugar your liver makes while improving insulin sensitivity, which helps reduce high blood sugar. <\/p>\n\n\n\n There are two types of metformin – regular and extended-release (XR). Extended-release metformin is taken once daily, whereas regular metformin is taken 2-3 times a day.<\/p>\n\n\n\n Metformin typically lowers A1c levels by around 1% and can be safely used with many other types of diabetes medications. Some of the major benefits of metformin are its safety, tolerance, affordability, and the fact that it doesn\u2019t cause low blood sugar (hypoglycemia).<\/p>\n\n\n\n Unlike Trulicity, you\u2019re not as likely to lose significant amounts of weight on metformin<\/a>, but you shouldn\u2019t gain any, either (it\u2019s considered a \u201cweight-neutral\u201d medication).<\/p>\n\n\n\n Sulfonylureas are a class of medications, including the popular medications glipizide, glyburide, and glimepiride. They are oral medications taken daily to help boost your body\u2019s insulin secretion. <\/p>\n\n\n\n Sulfonylureas come with a risk of hypoglycemia (low blood sugar), especially if you take them with other diabetes medications. <\/p>\n\n\n\n Sulfonylureas are generally less expensive than newer medications like Trulicity because there are generic options.<\/p>\n\n\n\n Several types of injectable insulins are used to treat type 1 and type 2 diabetes. Compared to other diabetes medications, insulin comes with the greatest risk of low blood sugar.<\/p>\n\n\n\n Insulin tends to be the most effective at lowering blood sugar because it can be customized to your lifestyle habits and blood sugar response. It does require daily injections, sometimes multiple times daily, which is a drawback to many patients.<\/p>\n\n\n\n There aren\u2019t any generic options for Trulicity, which is one of the reasons it\u2019s quite expensive when paying out of pocket. Expect to pay around $700-$800 for a month\u2019s supply of Trulicity at a 1.5 milligram\/week dose.<\/p>\n\n\n\n There isn\u2019t an oral alternative to Trulicity; it\u2019s only available as an injection. If you\u2019d like an oral GLP-1 receptor agonist, the only one currently on the market is Rybelsus (oral semaglutide).<\/p>\n\n\n\n According to a 2021 study<\/a>, berberine, tea, curcumin, cinnamon, wheat, soybean, resveratrol, and gardenia may all naturally boost GLP-1 concentrations and act as natural alternatives to Trulicity.<\/p>\n\n\n\n Natural alternatives generally aren\u2019t as potent or effective as prescription diabetes drugs, so you shouldn\u2019t stop taking any prescription to try natural alternatives without discussing it with your healthcare provider.<\/p>\n\n\n\n Berberine is a compound in some plants and is a natural alternative for treating insulin resistance and high blood sugar. Insulin resistance is associated with weight gain and overweight\/obesity.<\/p>\n\n\n\n According to a small study<\/a> on people with metabolic syndrome (a condition that can lead to type 2 diabetes), berberine improved insulin sensitivity and reduced the waist circumference of participants. <\/p>\n\n\n\n A pilot study compared metformin and berberine<\/a> directly for their ability to help treat symptoms of type 2 diabetes. The researchers found that berberine produced identical results as metformin<\/strong> in terms of improving blood glucose metabolism. <\/p>\n\n\n\n According to a meta-analysis<\/a> of ten randomized controlled trials, cinnamon can significantly reduce blood sugar levels, total cholesterol, LDL \u201cbad\u201d cholesterol, and triglyceride levels while increasing HDL \u201cgood\u201d cholesterol. However, cinnamon wasn\u2019t associated with significant reductions in A1c levels among test subjects. <\/p>\n\n\n\n If you can\u2019t tolerate the side effects of Trulicity<\/a> after several weeks, you may be advised to stop taking it and try another medication.<\/p>\n\n\n\n If you develop rarer complications from taking Trulicity, you\u2019ll be advised to stop taking it immediately.<\/p>\n\n\n\n If Trulicity isn\u2019t lowering your blood sugar levels as much as desired, you may want to try another medication to see if it\u2019s more effective.<\/p>\n\n\n\n Trulicity is expensive out-of-pocket, which can dissuade many people from taking it if it\u2019s not covered by healthcare or prescription insurance.<\/p>\n\n\n\n The most likely side effect of stopping Trulicity is that your blood sugar levels will increase, especially if you don\u2019t start taking another diabetes medication. <\/p>\n\n\n\n If you were experiencing any adverse side effects while taking Trulicity, they\u2019ll likely gradually diminish once you discontinue Trulicity.<\/p>\n\n\n\n You should work with your healthcare provider to stop taking Trulicity safely. If your blood sugar levels are high, you might be prescribed another medication to start taking once you stop Trulicity.<\/p>\n\n\n\n Trulicity can generally be stopped \u201ccold turkey\u201d without any ill effects. It will take around five days for half of the last dose of Trulicity to leave your system<\/a>, and several weeks for it to be eliminated from your body. <\/p>\n\n\n\n Trulicity is the brand name for dulaglutide, a GLP-1 receptor agonist meant to treat type 2 diabetes.<\/p>\n\n\n\n Some other prescription alternatives to Trulicity include other GLP-1 receptor agonists, metformin, sulfonylureas, and insulin.<\/p>\n\n\n\n While they may not be as effective, some natural alternatives to Trulicity include berberine, cinnamon, resveratrol, and curcumin, among others.<\/p>\n\n\n\n![\"how](\"https:\/\/blog.bensnaturalhealth.com\/wp-content\/uploads\/2023\/04\/HTRD-3-1.jpg\")
<\/a><\/figure>\n\n\n\nWhat are the side effects of Trulicity?<\/h2>\n\n\n\n
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Thyroid cancer<\/h3>\n\n\n\n
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Pancreatitis<\/h3>\n\n\n\n
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Pharmaceutical alternatives to Trulicity <\/h2>\n\n\n\n
Ozempic<\/h3>\n\n\n\n
Rybelsus<\/h3>\n\n\n\n
![\"rybelsus](\"https:\/\/blog.bensnaturalhealth.com\/wp-content\/uploads\/2022\/09\/rybelsus-vs-metformin-1024x256.jpg\")
<\/figure>\n\n\n\nBydureon BCise<\/h3>\n\n\n\n
Victoza<\/h3>\n\n\n\n
Metformin<\/h3>\n\n\n\n
![\"metformin](\"https:\/\/blog.bensnaturalhealth.com\/wp-content\/uploads\/2021\/11\/metformin-side-effects-1-1024x217.jpg\")
<\/figure>\n\n\n\nSulfonylureas<\/h3>\n\n\n\n
Insulin<\/h3>\n\n\n\n
![\"how](\"https:\/\/blog.bensnaturalhealth.com\/wp-content\/uploads\/2023\/04\/HTRD_Jenna-reviews.io-1.jpg\")
<\/a><\/figure>\n\n\n\nIs there a generic for Trulicity?<\/h2>\n\n\n\n
Is there an oral alternative to Trulicity?<\/h2>\n\n\n\n
Natural alternatives to Trulicity<\/h2>\n\n\n\n
Berberine<\/h3>\n\n\n\n
Cinnamon<\/h3>\n\n\n\n
![\"glyco](\"https:\/\/blog.bensnaturalhealth.com\/wp-content\/uploads\/2025\/10\/Glucose-Control-Inline-1.jpg\")
<\/a><\/figure>\n\n\n\nReasons people might stop taking Trulicity<\/h2>\n\n\n\n
Side effects<\/h3>\n\n\n\n
Complications<\/h3>\n\n\n\n
Not lowering your blood sugar enough<\/h3>\n\n\n\n
Cost<\/h3>\n\n\n\n
Are there any side effects of stopping Trulicity? <\/h2>\n\n\n\n
Stopping Trulicity safely<\/h2>\n\n\n\n
Conclusion<\/h2>\n\n\n\n
Explore More<\/h3>\n\n\n\n
![\"foods](\"https:\/\/blog.bensnaturalhealth.com\/wp-content\/uploads\/2022\/07\/foods-to-avoid-with-trulicity-1024x256.jpg\")
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