{"id":42437,"date":"2023-12-30T11:07:00","date_gmt":"2023-12-30T11:07:00","guid":{"rendered":"https:\/\/www.bensnaturalhealth.com\/blog\/?p=42437"},"modified":"2026-05-30T19:14:25","modified_gmt":"2026-05-30T19:14:25","slug":"parp-inhibitors-prostate-cancer","status":"publish","type":"post","link":"https:\/\/www.bensnaturalhealth.com\/blog\/prostate-health\/parp-inhibitors-prostate-cancer\/","title":{"rendered":"PARP Inhibitors For Cancer: Risks And Side Effects\u00a0"},"content":{"rendered":"<p>Researchers have come up with different treatment options for cancers.\u00a0And one of these is PARP inhibitors.\u00a0<\/p>\n<!-- \/wp:post-content -->\n\n<!-- wp:paragraph -->\n<p>The acronym \u201cPARP\u201d stands for poly adenosine diphosphate-ribose polymerase which is the name of an enzyme present in the human body.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>PARP inhibitor drugs are an effective new class of anticancer drugs.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:heading -->\n<h2 class=\"wp-block-heading\" id=\"h-what-is-a-parp-inhibitor\">What Is A PARP Inhibitor?<\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n<p>The very<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4806654\/\" target=\"_blank\" rel=\"noreferrer noopener nofollow\"> enzyme PARP<\/a> (PARP1 and 2) is responsible for helping in DNA damage repair to the cells.\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Thus, PARP inhibitor drugs work by preventing the cancer cell from repairing.\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>This, therefore, results in the death of the cancerous cells.\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:heading {\"level\":3} -->\n<h3 class=\"wp-block-heading\" id=\"h-targeted-cancer-therapy-nbsp\">Targeted Cancer Therapy\u00a0<\/h3>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n<p>Killer cancers require extreme care and attention.\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>So this is why healthcare providers employ targeted cancer therapies.\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Such therapies interfere with specific proteins involved in tumor formation.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S1471489208000829\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">Studies<\/a> have identified PARP inhibitor drugs can be as effective drugs in targeted therapy for cancer.\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p><\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:heading -->\n<h2 class=\"wp-block-heading\" id=\"h-main-parp-inhibitors\">Main PARP Inhibitors<\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n<p>The most common and main types of PARP inhibitors include:<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:list -->\n<ul><!-- wp:list-item -->\n<li>Talazoparib\u00a0<\/li>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<li>Rucaparib\u00a0<\/li>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<li>Olaparib\u00a0<\/li>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<li>Niraparib\u00a0<\/li>\n<!-- \/wp:list-item --><\/ul>\n<!-- \/wp:list -->\n\n<!-- wp:heading -->\n<h2 class=\"wp-block-heading\" id=\"h-how-do-they-work\">How Do They work?<\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n<p>As the name indicates, PARP inhibitors inhibit the activity of PARP enzymes.\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>This anti-cancer treatment is effective and uses a process we call <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3018572\/\">s<\/a><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3018572\/\" target=\"_blank\" rel=\"noreferrer noopener\">y<\/a><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3018572\/\" rel=\"noreferrer noopener nofollow\" target=\"_blank\">nthetic lethality<\/a>.\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>It is defined as a type of genetic interaction where there is the occurrence of two genetic events simultaneously.\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>This co-occurrence results in cancer cell death.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Moreover, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31625002\/\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">research<\/a> shows that PARP inhibitor treatment takes advantage of synthetic lethality and induces cell death by exploiting a defect in DNA repair.\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>PARP inhibitors are most effective against tumors arising in patients with<a href=\"https:\/\/science.sciencemag.org\/content\/355\/6330\/1152.abstract\" target=\"_blank\" rel=\"noreferrer noopener nofollow\"> germline mutation<\/a>.\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>This is because they have a specific type of DNA repair defect which the drug exploits.\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>The drugs can work effectively in combination with other treatment modalities and medications such as temozolomide.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:heading -->\n<h2 class=\"wp-block-heading\" id=\"h-how-parp-inhibitors-manage-cancer\">How PARP inhibitors Manage Cancer<\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n<p>PARP inhibitors carry out synthetic lethality in cancers where there are susceptibility proteins i.e. BRCA 1 and BRCA2.\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>These drugs then hamper the base excision repair (BER) that is important for the overall survival of the cancerous cells.\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>This and other deficiencies in the HR pathway then lead to tumor cell death.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Similarly, PTEN-deficient cancerous cells are more sensitive to PARP inhibitors.\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>When managing cancer, we can use PARP inhibitor treatment as single agents or in combination with other anti-cancer therapies.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:heading {\"level\":3} -->\n<h3 class=\"wp-block-heading\" id=\"h-as-single-agents\">As Single Agents<\/h3>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n<p>PARP inhibitors kill BRCA-2 deficient cells as single agents and are more potent (3 times) than cisplatin cytotoxicity.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:heading {\"level\":3} -->\n<h3 class=\"wp-block-heading\" id=\"h-in-combination-with-cytotoxic-therapy-nbsp\">In Combination With Cytotoxic Therapy\u00a0<\/h3>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n<p>We can use PARP inhibitors with DNA methylating agents such as temozolomide.\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Moreover, a<a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0140988\" target=\"_blank\" rel=\"noreferrer noopener nofollow\"> study<\/a> suggests that a superior anti-cancer effect is achieved with the combination of PARP inhibitor and temozolomide in the management of Ewing\u2019s sarcoma.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:heading {\"level\":3} -->\n<h3 class=\"wp-block-heading\" id=\"h-in-combination-with-ionizing-radiation-nbsp\">In Combination With Ionizing Radiation\u00a0<\/h3>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n<p>The efficacious drug PARP inhibitor effectively potentiates ionizing radiation via the inhibition of BER.\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>According to a<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17088286\/\" target=\"_blank\" rel=\"noreferrer noopener nofollow\"> study<\/a>, we can achieve a great anti-cancer effect when pairing radiotherapy (XRT) with PARP-1 inhibitors.\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:heading -->\n<h2 class=\"wp-block-heading\" id=\"h-types-of-cancer-that-parp-inhibitors-can-work-for\">Types Of Cancer That PARP Inhibitors Can Work For<\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:heading {\"level\":3} -->\n<h3 class=\"wp-block-heading\" id=\"h-breast-cancer-nbsp\">Breast Cancer\u00a0<\/h3>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n<p>PARP inhibition was<a href=\"https:\/\/bmcmedicine.biomedcentral.com\/articles\/10.1186\/s12916-015-0425-1\" target=\"_blank\" rel=\"noreferrer noopener nofollow\"> found to be<\/a> a promising strategy in the treatment of breast cancers that are associated with BRCA mutation 1\/2.\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>The treatment method is also effective in curing papillary serous ovarian cancers.\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>A<a href=\"https:\/\/link.springer.com\/article\/10.1007\/s11864-018-0540-2\" target=\"_blank\" rel=\"noreferrer noopener nofollow\"> study<\/a> validates the use of PARP inhibitors as adjuvant therapy in the treatment of breast cancer.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:heading {\"level\":3} -->\n<h3 class=\"wp-block-heading\" id=\"h-ovarian-cancer-nbsp\">Ovarian Cancer\u00a0<\/h3>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n<p>Ovarian cancer is a leading killer in women.\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>It is fifth in cancer deaths among women.\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Further, PARP inhibitors are flag-bearers of<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0923753419316230\" target=\"_blank\" rel=\"noreferrer noopener nofollow\"> change in the management of ovarian cancer<\/a>.\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>This type of drug is pretty effective as a therapeutic agent by<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0305737218302007\" target=\"_blank\" rel=\"noreferrer noopener nofollow\"> inducing synthetic lethality<\/a> in ovarian cancer.\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>FDA\/EMA approved PARP inhibitors for ovarian cancer include:<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:list -->\n<ul><!-- wp:list-item -->\n<li>Olaparib\u00a0<\/li>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<li>Rucaparib\u00a0<\/li>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<li>Niraparib\u00a0<\/li>\n<!-- \/wp:list-item --><\/ul>\n<!-- \/wp:list -->\n\n<!-- wp:paragraph -->\n<p>Keeping in mind the efficacy of PARP inhibitors, these are being launched for newly diagnosed germline BRCA cancers and platinum-sensitive<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0090825814002030\" target=\"_blank\" rel=\"noreferrer noopener nofollow\"> recurrent ovarian cancer<\/a>.\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>PARP inhibitors show promising activity against BRCA mutated ovarian cancer.\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Rucaprib can be advantageous in the treatment of a variety of cancers including:<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:list -->\n<ul><!-- wp:list-item -->\n<li>Ovarian\u00a0<\/li>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<li>Peritoneal\u00a0<\/li>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<li>Fallopian tube\u00a0<\/li>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<li>Prostate\u00a0<\/li>\n<!-- \/wp:list-item --><\/ul>\n<!-- \/wp:list -->\n\n<!-- wp:heading {\"level\":3} -->\n<h3 class=\"wp-block-heading\" id=\"h-pancreatic-cancer-nbsp\">Pancreatic Cancer\u00a0<\/h3>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n<p>BRCA associated pancreatic cancer can be effectively managed using PARP inhibitors, as suggested by a<a href=\"http:\/\/www.tema.unina.it\/index.php\/jop\/article\/view\/2690\"> study<\/a>.\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>It is considered to be more beneficial as compared to chemotherapy for this type of cancer.\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>It has evolved as a new therapeutic opportunity.<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1574789112001007\">\u00a0<\/a><\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1574789112001007\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">Research<\/a> suggests that radiochemotherapy can be better optimized using PARP inhibitors in the treatment of pancreatic cancer.\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>The drugs are considered effective chemo-radiosensitizers, which therefore means that giving PARP inhibitors to cancer patients increases their sensitivity to chemotherapy and radiotherapy for cancer treatments.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:heading {\"level\":3} -->\n<h3 class=\"wp-block-heading\" id=\"h-prostate-cancer-nbsp\">Prostate Cancer\u00a0<\/h3>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n<p>These drugs seem to help in the management of <a href=\"https:\/\/blog.bensnaturalhealth.com\/prostate-cancer\/\" target=\"_blank\" rel=\"noreferrer noopener\">prostate cancer<\/a> as well.<a href=\"https:\/\/link.springer.com\/article\/10.1007\/s11864-017-0480-2\">\u00a0<\/a><\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p><a href=\"https:\/\/link.springer.com\/article\/10.1007\/s11864-017-0480-2\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">Studies<\/a> suggest that we can achieve far better results when we pair PARP therapy with chemo-, radio-, and hormonal therapies, etc.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Furthermore, as per a<a href=\"https:\/\/www.mdpi.com\/2073-4425\/10\/8\/565\" target=\"_blank\" rel=\"noreferrer noopener nofollow\"> 2019 study<\/a>, targeting the DNA repair pathway can render prostate cancer inactive and weak to survive.\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Nicaparib is not very effective for prostate cancer.\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Moreover, other types of cancers for which PARP inhibitors are good for usage include:<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:list -->\n<ul><!-- wp:list-item -->\n<li>Peritoneal cancer<\/li>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<li>Fallopian tube cancer<\/li>\n<!-- \/wp:list-item --><\/ul>\n<!-- \/wp:list -->\n\n<!-- wp:heading -->\n<h2 class=\"wp-block-heading\" id=\"h-do-parp-inhibitors-affect-normal-cells\">Do PARP Inhibitors Affect Normal Cells?<\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n<p>The most important question about any anti-cancer drug is if it affects normal cells.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Anti-cancer drugs that do not affect the normal cells are recommended.\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Olaparib is an FDA-approved PARP inhibitor therapy that is indicated in the treatment of patients suffering from breast cancer, prostate cancer, and lung cancer.\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>PARP inhibitor therapy does not seem to affect normal, non-cancerous cells.\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>As cancerous cells grow and multiply quickly compared to normal cells, PARP inhibitors only target the abnormally multiplying cells.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:heading -->\n<h2 class=\"wp-block-heading\" id=\"h-risks-and-side-effects-nbsp\">Risks And Side Effects\u00a0<\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n<p>All PARP inhibitors seem to have the following side effects:<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:list -->\n<ul><!-- wp:list-item -->\n<li>A loss of appetite\u00a0<\/li>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<li>Changes in taste sensation<\/li>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<li>Nausea\u00a0<\/li>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<li><a href=\"https:\/\/blog.bensnaturalhealth.com\/cancer-treatment-nausea-home-remedies\/\" target=\"_blank\" rel=\"noreferrer noopener\">Vomiting<\/a>\u00a0<\/li>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<li>Diarrhea\u00a0<\/li>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<li>Fatigue\u00a0<\/li>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<li>Stomach ache and indigestion<\/li>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<li>Muscles and joint aches\u00a0<\/li>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<li>Lethargy and fatigue<\/li>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<li>Headaches\u00a0<\/li>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<li>Dizziness\u00a0<\/li>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<li>Increased risk of infection and bleeding\u00a0<\/li>\n<!-- \/wp:list-item --><\/ul>\n<!-- \/wp:list -->\n\n<!-- wp:paragraph -->\n<p>Further, a<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7292736\/\" target=\"_blank\" rel=\"noreferrer noopener nofollow\"> study<\/a> suggests that toxicities induced by a PARP inhibitor can be managed with supportive care and dose reduction.\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>However, your healthcare provider must give you appropriate counseling before the start of the treatment.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:heading -->\n<h2 class=\"wp-block-heading\" id=\"h-what-to-discuss-with-your-doctor\">What To Discuss With Your Doctor<\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n<p>As already mentioned, counseling before the beginning of the treatment is crucial. Therefore, you must gain appropriate knowledge pre-hand.\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>You must ask your doctor about the following points:<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:list -->\n<ul><!-- wp:list-item -->\n<li>Possible side effects and drug interactions \u00a0<\/li>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<li>Management of side effects\u00a0<\/li>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<li>Risks involved with the therapy<\/li>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<li>And effectiveness of the treatment (how it has helped other patients)<\/li>\n<!-- \/wp:list-item --><\/ul>\n<!-- \/wp:list -->\n\n<!-- wp:paragraph -->\n<p>You should also inform your doctor about any other medications, and remedies used to make sure that it doesn\u2019t interfere with the treatment.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:heading -->\n<h2 class=\"wp-block-heading\" id=\"h-conclusion-nbsp\">Conclusion\u00a0<\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n<p>So, PARP inhibitors are specialized anti-cancer drugs that target the PARP enzyme in the body.\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>This enzyme is responsible for repairing the DNA damage to cancer cells. Abstinence of enzymatic action means tumor cell death.\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>Moreover, the most common drugs are rucaparib, olaparib, talazoparib and niraparib.\u00a0<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>These drugs are most effective against BRCA mutation cancers such as ovarian, fallopian tube, peritoneal, breast, and prostate cancer.\u00a0<\/p>\n<!-- \/wp:paragraph -->","protected":false},"excerpt":{"rendered":"<p>Researchers have come up with different treatment options for cancers.\u00a0And one of these is PARP inhibitors.\u00a0 The acronym \u201cPARP\u201d stands for poly adenosine diphosphate-ribose polymerase which is the name of an enzyme present in the human body. PARP inhibitor drugs are an effective new class of anticancer drugs. What Is A PARP Inhibitor? The very [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":29068,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[1],"tags":[],"health_topic":[132,124],"class_list":["post-42437","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog","health_topic-prostate-cancer-topic","health_topic-prostate-health"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.2 (Yoast SEO v27.5) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>PARP Inhibitors For Cancer: Risks And Side Effects\u00a0 - Ben&#039;s Natural Health<\/title>\n<meta name=\"description\" content=\"PARP inhibitors are an effective treatment option for cancer. 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