{"id":42437,"date":"2023-12-30T11:07:00","date_gmt":"2023-12-30T11:07:00","guid":{"rendered":"https:\/\/www.bensnaturalhealth.com\/blog\/?p=42437"},"modified":"2026-07-07T11:05:09","modified_gmt":"2026-07-07T11:05:09","slug":"parp-inhibitors-prostate-cancer","status":"publish","type":"post","link":"https:\/\/www.bensnaturalhealth.com\/blog\/prostate-health\/parp-inhibitors-prostate-cancer\/","title":{"rendered":"PARP Inhibitors For Cancer: Risks And Side Effects\u00a0"},"content":{"rendered":"Researchers have come up with different treatment options for cancers.\u00a0And one of these is PARP inhibitors.\n\n<!-- \/wp:post-content -->\n\n<!-- wp:paragraph -->\n\nThe acronym \u201cPARP\u201d stands for poly adenosine diphosphate-ribose polymerase which is the name of an enzyme present in the human body.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nPARP inhibitor drugs are an effective new class of anticancer drugs.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:heading -->\n<h2 id=\"h-what-is-a-parp-inhibitor\" class=\"wp-block-heading\">What Is A PARP Inhibitor?<\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n\nThe very<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4806654\/\" target=\"_blank\" rel=\"noreferrer noopener nofollow\"> enzyme PARP<\/a> (PARP1 and 2) is responsible for helping in DNA damage repair to the cells.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nThus, PARP inhibitor drugs work by preventing the cancer cell from repairing.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nThis, therefore, results in the death of the cancerous cells.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:heading {\"level\":3} -->\n<h3 id=\"h-targeted-cancer-therapy-nbsp\" class=\"wp-block-heading\">Targeted Cancer Therapy<\/h3>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n\nKiller cancers require extreme care and attention.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nSo this is why healthcare providers employ targeted cancer therapies.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nSuch therapies interfere with specific proteins involved in tumor formation.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\n<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S1471489208000829\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">Studies<\/a> have identified PARP inhibitor drugs can be as effective drugs in targeted therapy for cancer.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:heading -->\n<h2 id=\"h-main-parp-inhibitors\" class=\"wp-block-heading\">Main PARP Inhibitors<\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n\nThe most common and main types of PARP inhibitors include:\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:list -->\n<ul>\n \t<li style=\"list-style-type: none;\">\n<ul><!-- wp:list-item -->\n \t<li>Talazoparib<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<ul>\n \t<li style=\"list-style-type: none;\">\n<ul>\n \t<li>Rucaparib<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<ul>\n \t<li style=\"list-style-type: none;\">\n<ul>\n \t<li>Olaparib<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<ul>\n \t<li style=\"list-style-type: none;\">\n<ul>\n \t<li>Niraparib<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<!-- \/wp:list-item -->\n\n<!-- \/wp:list -->\n\n<!-- wp:heading -->\n<h2 id=\"h-how-do-they-work\" class=\"wp-block-heading\">How Do They work?<\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n\nAs the name indicates, PARP inhibitors inhibit the activity of PARP enzymes.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nThis anti-cancer treatment is effective and uses a process we call <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3018572\/\">s<\/a><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3018572\/\" target=\"_blank\" rel=\"noreferrer noopener\">y<\/a><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3018572\/\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">nthetic lethality<\/a>.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nIt is defined as a type of genetic interaction where there is the occurrence of two genetic events simultaneously.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nThis co-occurrence results in cancer cell death.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nMoreover, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31625002\/\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">research<\/a> shows that PARP inhibitor treatment takes advantage of synthetic lethality and induces cell death by exploiting a defect in DNA repair.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nPARP inhibitors are most effective against tumors arising in patients with<a href=\"https:\/\/science.sciencemag.org\/content\/355\/6330\/1152.abstract\" target=\"_blank\" rel=\"noreferrer noopener nofollow\"> germline mutation<\/a>.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nThis is because they have a specific type of DNA repair defect which the drug exploits.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nThe drugs can work effectively in combination with other treatment modalities and medications such as temozolomide.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:heading -->\n<h2 id=\"h-how-parp-inhibitors-manage-cancer\" class=\"wp-block-heading\">How PARP inhibitors Manage Cancer<\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n\nPARP inhibitors carry out synthetic lethality in cancers where there are susceptibility proteins i.e. BRCA 1 and BRCA2.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nThese drugs then hamper the base excision repair (BER) that is important for the overall survival of the cancerous cells.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nThis and other deficiencies in the HR pathway then lead to tumor cell death.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nSimilarly, PTEN-deficient cancerous cells are more sensitive to PARP inhibitors.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nWhen managing cancer, we can use PARP inhibitor treatment as single agents or in combination with other anti-cancer therapies.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:heading {\"level\":3} -->\n<h3 id=\"h-as-single-agents\" class=\"wp-block-heading\">As Single Agents<\/h3>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n\nPARP inhibitors kill BRCA-2 deficient cells as single agents and are more potent (3 times) than cisplatin cytotoxicity.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:heading {\"level\":3} -->\n<h3 id=\"h-in-combination-with-cytotoxic-therapy-nbsp\" class=\"wp-block-heading\">In Combination With Cytotoxic Therapy<\/h3>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n\nWe can use PARP inhibitors with DNA methylating agents such as temozolomide.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nMoreover, a<a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0140988\" target=\"_blank\" rel=\"noreferrer noopener nofollow\"> study<\/a> suggests that a superior anti-cancer effect is achieved with the combination of PARP inhibitor and temozolomide in the management of Ewing\u2019s sarcoma.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:heading {\"level\":3} -->\n<h3 id=\"h-in-combination-with-ionizing-radiation-nbsp\" class=\"wp-block-heading\">In Combination With Ionizing Radiation<\/h3>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n\nThe efficacious drug PARP inhibitor effectively potentiates ionizing radiation via the inhibition of BER.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nAccording to a<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17088286\/\" target=\"_blank\" rel=\"noreferrer noopener nofollow\"> study<\/a>, we can achieve a great anti-cancer effect when pairing radiotherapy (XRT) with PARP-1 inhibitors.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:heading -->\n<h2 id=\"h-types-of-cancer-that-parp-inhibitors-can-work-for\" class=\"wp-block-heading\">Types Of Cancer That PARP Inhibitors Can Work For<\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:heading {\"level\":3} -->\n<h3 id=\"h-breast-cancer-nbsp\" class=\"wp-block-heading\">Breast Cancer<\/h3>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n\nPARP inhibition was<a href=\"https:\/\/bmcmedicine.biomedcentral.com\/articles\/10.1186\/s12916-015-0425-1\" target=\"_blank\" rel=\"noreferrer noopener nofollow\"> found to be<\/a> a promising strategy in the treatment of breast cancers that are associated with BRCA mutation 1\/2.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nThe treatment method is also effective in curing papillary serous ovarian cancers.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nA<a href=\"https:\/\/link.springer.com\/article\/10.1007\/s11864-018-0540-2\" target=\"_blank\" rel=\"noreferrer noopener nofollow\"> study<\/a> validates the use of PARP inhibitors as adjuvant therapy in the treatment of breast cancer.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:heading {\"level\":3} -->\n<h3 id=\"h-ovarian-cancer-nbsp\" class=\"wp-block-heading\">Ovarian Cancer<\/h3>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n\nOvarian cancer is a leading killer in women.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nIt is fifth in cancer deaths among women.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nFurther, PARP inhibitors are flag-bearers of<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0923753419316230\" target=\"_blank\" rel=\"noreferrer noopener nofollow\"> change in the management of ovarian cancer<\/a>.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nThis type of drug is pretty effective as a therapeutic agent by<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0305737218302007\" target=\"_blank\" rel=\"noreferrer noopener nofollow\"> inducing synthetic lethality<\/a> in ovarian cancer.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nFDA\/EMA approved PARP inhibitors for ovarian cancer include:\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:list -->\n<ul>\n \t<li style=\"list-style-type: none;\">\n<ul><!-- wp:list-item -->\n \t<li>Olaparib<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<ul>\n \t<li style=\"list-style-type: none;\">\n<ul>\n \t<li>Rucaparib<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<ul>\n \t<li style=\"list-style-type: none;\">\n<ul>\n \t<li>Niraparib<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<!-- \/wp:list-item -->\n\n<!-- \/wp:list -->\n\n<!-- wp:paragraph -->\n\nKeeping in mind the efficacy of PARP inhibitors, these are being launched for newly diagnosed germline BRCA cancers and platinum-sensitive<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0090825814002030\" target=\"_blank\" rel=\"noreferrer noopener nofollow\"> recurrent ovarian cancer<\/a>.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nPARP inhibitors show promising activity against BRCA mutated ovarian cancer.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nRucaprib can be advantageous in the treatment of a variety of cancers including:\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:list -->\n<ul>\n \t<li style=\"list-style-type: none;\">\n<ul><!-- wp:list-item -->\n \t<li>Ovarian<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<ul>\n \t<li style=\"list-style-type: none;\">\n<ul>\n \t<li>Peritoneal<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<ul>\n \t<li style=\"list-style-type: none;\">\n<ul>\n \t<li>Fallopian tube<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<ul>\n \t<li style=\"list-style-type: none;\">\n<ul>\n \t<li>Prostate<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<!-- \/wp:list-item -->\n\n<!-- \/wp:list -->\n\n<!-- wp:heading {\"level\":3} -->\n<h3 id=\"h-pancreatic-cancer-nbsp\" class=\"wp-block-heading\">Pancreatic Cancer<\/h3>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n\nBRCA associated pancreatic cancer can be effectively managed using PARP inhibitors, as suggested by a study.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nIt is considered to be more beneficial as compared to chemotherapy for this type of cancer.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nIt has evolved as a new therapeutic opportunity.<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1574789112001007\">\u00a0<\/a>\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\n<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1574789112001007\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">Research<\/a> suggests that radiochemotherapy can be better optimized using PARP inhibitors in the treatment of pancreatic cancer.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nThe drugs are considered effective chemo-radiosensitizers, which therefore means that giving PARP inhibitors to cancer patients increases their sensitivity to chemotherapy and radiotherapy for cancer treatments.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:heading {\"level\":3} -->\n<h3 id=\"h-prostate-cancer-nbsp\" class=\"wp-block-heading\">Prostate Cancer<\/h3>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n\nThese drugs seem to help in the management of <a href=\"https:\/\/www.bensnaturalhealth.com\/blog\/prostate-cancer\/\" target=\"_blank\" rel=\"noreferrer noopener\">prostate cancer<\/a> as well.<a href=\"https:\/\/link.springer.com\/article\/10.1007\/s11864-017-0480-2\">\u00a0<\/a>\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\n<a href=\"https:\/\/link.springer.com\/article\/10.1007\/s11864-017-0480-2\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">Studies<\/a> suggest that we can achieve far better results when we pair PARP therapy with chemo-, radio-, and hormonal therapies, etc.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nFurthermore, as per a<a href=\"https:\/\/www.mdpi.com\/2073-4425\/10\/8\/565\" target=\"_blank\" rel=\"noreferrer noopener nofollow\"> 2019 study<\/a>, targeting the DNA repair pathway can render prostate cancer inactive and weak to survive.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nNicaparib is not very effective for prostate cancer.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nMoreover, other types of cancers for which PARP inhibitors are good for usage include:\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:list -->\n<ul>\n \t<li style=\"list-style-type: none;\">\n<ul><!-- wp:list-item -->\n \t<li>Peritoneal cancer<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<ul>\n \t<li style=\"list-style-type: none;\">\n<ul>\n \t<li>Fallopian tube cancer<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<!-- \/wp:list-item -->\n\n<!-- \/wp:list -->\n\n<!-- wp:heading -->\n<h2 id=\"h-do-parp-inhibitors-affect-normal-cells\" class=\"wp-block-heading\">Do PARP Inhibitors Affect Normal Cells?<\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n\nThe most important question about any anti-cancer drug is if it affects normal cells.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nAnti-cancer drugs that do not affect the normal cells are recommended.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nOlaparib is an FDA-approved PARP inhibitor therapy that is indicated in the treatment of patients suffering from breast cancer, prostate cancer, and lung cancer.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nPARP inhibitor therapy does not seem to affect normal, non-cancerous cells.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nAs cancerous cells grow and multiply quickly compared to normal cells, PARP inhibitors only target the abnormally multiplying cells.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:heading -->\n<h2 id=\"h-risks-and-side-effects-nbsp\" class=\"wp-block-heading\">Risks And Side Effects<\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n\nAll PARP inhibitors seem to have the following side effects:\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:list -->\n<ul>\n \t<li style=\"list-style-type: none;\">\n<ul><!-- wp:list-item -->\n \t<li>A loss of appetite<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<ul>\n \t<li style=\"list-style-type: none;\">\n<ul>\n \t<li>Changes in taste sensation<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<ul>\n \t<li style=\"list-style-type: none;\">\n<ul>\n \t<li>Nausea<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<ul>\n \t<li style=\"list-style-type: none;\">\n<ul>\n \t<li><a href=\"https:\/\/www.bensnaturalhealth.com\/blog\/cancer-treatment-nausea-home-remedies\/\" target=\"_blank\" rel=\"noreferrer noopener\">Vomiting<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<ul>\n \t<li style=\"list-style-type: none;\">\n<ul>\n \t<li>Diarrhea<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<ul>\n \t<li style=\"list-style-type: none;\">\n<ul>\n \t<li>Fatigue<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<ul>\n \t<li style=\"list-style-type: none;\">\n<ul>\n \t<li>Stomach ache and indigestion<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<ul>\n \t<li style=\"list-style-type: none;\">\n<ul>\n \t<li>Muscles and joint aches<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<ul>\n \t<li style=\"list-style-type: none;\">\n<ul>\n \t<li>Lethargy and fatigue<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<ul>\n \t<li style=\"list-style-type: none;\">\n<ul>\n \t<li>Headaches<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<ul>\n \t<li style=\"list-style-type: none;\">\n<ul>\n \t<li>Dizziness<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<ul>\n \t<li style=\"list-style-type: none;\">\n<ul>\n \t<li>Increased risk of infection and bleeding<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<!-- \/wp:list-item -->\n\n<!-- \/wp:list -->\n\n<!-- wp:paragraph -->\n\nFurther, a<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7292736\/\" target=\"_blank\" rel=\"noreferrer noopener nofollow\"> study<\/a> suggests that toxicities induced by a PARP inhibitor can be managed with supportive care and dose reduction.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nHowever, your healthcare provider must give you appropriate counseling before the start of the treatment.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:heading -->\n<h2 id=\"h-what-to-discuss-with-your-doctor\" class=\"wp-block-heading\">What To Discuss With Your Doctor<\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n\nAs already mentioned, counseling before the beginning of the treatment is crucial. Therefore, you must gain appropriate knowledge pre-hand.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nYou must ask your doctor about the following points:\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:list -->\n<ul>\n \t<li style=\"list-style-type: none;\">\n<ul><!-- wp:list-item -->\n \t<li>Possible side effects and drug interactions<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<ul>\n \t<li style=\"list-style-type: none;\">\n<ul>\n \t<li>Management of side effects<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<ul>\n \t<li style=\"list-style-type: none;\">\n<ul>\n \t<li>Risks involved with the therapy<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<!-- \/wp:list-item -->\n\n<!-- wp:list-item -->\n<ul>\n \t<li style=\"list-style-type: none;\">\n<ul>\n \t<li>And effectiveness of the treatment (how it has helped other patients)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<!-- \/wp:list-item -->\n\n<!-- \/wp:list -->\n\n<!-- wp:paragraph -->\n\nYou should also inform your doctor about any other medications, and remedies used to make sure that it doesn\u2019t interfere with the treatment.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:heading -->\n<h2 id=\"h-conclusion-nbsp\" class=\"wp-block-heading\">Conclusion<\/h2>\n<!-- \/wp:heading -->\n\n<!-- wp:paragraph -->\n\nSo, PARP inhibitors are specialized anti-cancer drugs that target the PARP enzyme in the body.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nThis enzyme is responsible for repairing the DNA damage to cancer cells. Abstinence of enzymatic action means tumor cell death.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nMoreover, the most common drugs are rucaparib, olaparib, talazoparib and niraparib.\n\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n\nThese drugs are most effective against BRCA mutation cancers such as ovarian, fallopian tube, peritoneal, breast, and prostate cancer.\n\n<!-- \/wp:paragraph -->","protected":false},"excerpt":{"rendered":"<p>Researchers have come up with different treatment options for cancers.\u00a0And one of these is PARP inhibitors. The acronym \u201cPARP\u201d stands for poly adenosine diphosphate-ribose polymerase which is the name of an enzyme present in the human body. PARP inhibitor drugs are an effective new class of anticancer drugs. What Is A PARP Inhibitor? The very [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":29068,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[1],"tags":[],"health_topic":[132,124],"class_list":["post-42437","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog","health_topic-prostate-cancer-topic","health_topic-prostate-health"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.2 (Yoast SEO v27.5) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>PARP Inhibitors For Cancer: Risks And Side Effects | Guide<\/title>\n<meta name=\"description\" content=\"PARP inhibitors are an effective treatment option for cancer. 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