Ozempic and Periods: How It Affects The Menstrual Cycle

Are you using Ozempic and wondering how it can affect your period (menstrual cycle)? 

Or are you considering starting the drug and thinking about all the possible side effects?

Ozempic (semaglutide) is an anti-diabetic medication used in the management of type 2 diabetes. 

As a woman, the effect Ozempic can have on your menses is an important consideration.

It is particularly important if you are thinking about using Ozempic to manage both PCOS and type 2 diabetes.  

In this article, we tell you everything you need to know about the possible effects of Ozempic on your menstrual cycle.

Does Ozempic affect your menstrual cycle?

There is currently no evidence suggesting that the Ozempic can directly affect menstrual cycles. 

However, some individuals have complained about changes to their menstrual cycle while taking Ozempic. 

Is the drug responsible for these changes? The simple answer is we don’t know yet. 

Approved by the FDA in 2017, Ozempic is still a relatively new drug. So, more research is needed in this area.  

It is, however, possible that Semaglutide indirectly affects the menstrual cycle in a few ways:

Weight loss

While it is not yet approved as a weight-loss medication, Ozempic has been shown to cause significant drops in pounds in people who use it. 

The drug can delay gastric emptying. This makes you feel full faster, causing you to eat less and putting your body in a caloric deficit.

If you are in a state of caloric deficit and experience drastic weight loss, your period may become irregular or completely stop. 

Basically, your body halts your cycle because you don’t have enough resources to support a pregnancy.

Hormonal changes

Due to reasons that are not yet well understood, high sugar levels can affect the hormones that regulate menstruation and lead to irregular or missed periods

To put it simply, diabetes itself can affect your menstrual cycle. Since Ozempic helps to regulate blood sugar levels, it may lead to more regular menstrual cycles in some individuals with diabetes.

It is also possible for menstrual changes while using the drug to be due to completely unrelated causes. These include pregnancy, chronic illnesses, and menopause.

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Can Ozempic completely stop your period?

For women who previously had regular menstrual cycles, extreme weight loss induced by Ozempic can bring their cycles to a complete stop. This is referred to as amenorrhea.

Weight-loss-related amenorrhea falls under the umbrella of functional hypothalamic amenorrhea (FHA). 

Other types of FHA include exercise-related amenorrhea (commonly seen in female athletes who engage in rigorous physical activity) and stress-related amenorrhea.

The good news is that FHA is a reversible condition. Once your weight stabilizes, your cycle should return to normal with no long-term effect on your fertility.

How can you prevent a missed period on Ozempic?

It is best to lose weight slowly and at a steady pace while on drugs like Ozempic, Wegovy, and Mounjaro. 

Apart from menstrual changes, rapid weight loss can cause other undesirable effects like fatigue, hair loss, Ozempic face, and Ozempic butt

Here are some tips that may help prevent these:

Watch your diet

While using Ozempic, your body may have to adapt to a sudden drop in the number of calories you consume. 

One of the best ways to combat this and ensure that you are giving your body enough time to adjust is by eating a healthy and balanced diet.

Talk to your doctor about weight-loss targets, expected timeframes, exercise, and dietary patterns. 

Follow whatever recommendations they give you, as deviating from these may result in too rapid weight loss.

Use the prescribed dosage

Ensure that you only use the dose recommended by your doctor. Do not make changes to your regimen without discussing it with them. 

Using too much Ozempic can lead to more severe side effects.

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Can Ozempic help regulate your period if you have PCOS?

PCOS (Polycystic Ovarian Syndrome) is a common hormonal condition that affects women of reproductive age. It has a strong link with type 2 diabetes. 

According to the CDC, more than half of women with PCOS go on to develop type 2 diabetes by 40 years of age. 

A high body mass index (BMI) contributes to irregular menstrual cycles and is often associated with PCOS. 

Because Ozempic can help people manage their weight, it may also help regulate periods in people with PCOS.

Besides managing weight and helping with period regulation, Ozempic has other benefits for women with PCOS. 

It helps with insulin resistance by increasing insulin sensitivity and production. It also lowers the risk of cardiovascular disease and non-alcoholic fatty liver disease, conditions that can be associated with PCOS.

Should I stop Ozempic if it affects my menstruation?

If you experience changes to your menstrual cycle while using Ozempic, contact your doctor as soon as possible. 

You shouldn’t stop any anti-diabetic medication without first discussing it with your doctor.

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Ozempic is a medication that regulates blood sugar levels and is beneficial for weight loss. Although there currently is no available evidence that it has an impact on the menstrual cycle, some users have reported changes in their menses while using the drug.

Menstrual changes may be due to the indirect effects of the drug. In women who previously had uncontrolled blood sugar and menstrual irregularities, Ozempic may help control sugar levels and potentially help regulate their menstrual cycle. In women who previously had regular periods, rapid loss of weight may cause late, irregular, or completely halted periods. However, these changes normally stop once weight stabilizes.

If you notice abnormal changes in your menstrual cycle while taking Ozempic, it’s vital to consult your healthcare provider.

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  1. Chen L, Lu Y, Zhou YF, Wang Y, Zhan HF, Zhao YT, Wang YL, Zhang FF, Chen H, Li X. The effects of weight loss-related amenorrhea on women’s health and the therapeutic approaches: a narrative review. Ann Transl Med. 2023 Jan 31;11(2):132. doi: 10.21037/atm-22-6366. PMID: 36819572; PMCID: PMC9929756.
  2. Meczekalski B, Katulski K, Czyzyk A, Podfigurna-Stopa A, Maciejewska-Jeske M. Functional hypothalamic amenorrhea and its influence on women’s health. J Endocrinol Invest. 2014 Nov;37(11):1049-56. doi: 10.1007/s40618-014-0169-3. Epub 2014 Sep 9. PMID: 25201001; PMCID: PMC4207953.
  3. CDC. PCOS (Polycystic Ovary Syndrome) and Diabetes.

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