Mounjaro Contraindications: Who Should Not Take Tirzepatide?

Mounjaro (Tirzepatide) is a prescription medication used for the treatment of type 2 diabetes. 

Using Mounjaro is contraindicated for patients who have certain medical conditions or are taking other medications that can cause drug interactions.

Below, we share a list of Mounjaro contraindications, medication interactions, and who should avoid taking this drug.

Mounjaro Contraindications You Must Be Aware of

1) Thyroid Cancer

If you or someone in your family has a history of medullary thyroid cancer, the use of Mounjaro would be contraindicated for you. 

Mounjaro has a boxed warning as it could increase the risk of medullary thyroid cancer.

2) MEN 2

The use of Mounjaro is not suitable for patients with MEN 2 (multiple endocrine neoplasia syndrome type 2).

MEN 2 is a rare condition that can increase the risk of developing thyroid tumors. Due to this risk, Mounjaro is contraindicated for patients with this syndrome.

3) Allergy to Mounjaro

If you have a history of an allergic reaction to Mounjaro or its ingredients, your doctor will not prescribe this medication to you. 

4) History Of Pancreatitis (Inflammation of The Pancreas)

Patients who have pancreatitis should refrain from using Mounjaro. They should stop using Mounjaro and contact their doctor immediately if they notice any sign of pancreatitis, such as severe pain in the upper part of the abdomen, nausea, and vomiting.

5) Hypoglycemia (Low Blood Sugar)

Your risk for hypoglycemia can increase when you use Mounjaro with other medications that lower the blood sugar level, such as insulin or sulfonylurea. 

Hence, patients using these medications need to be cautious while using Mounjaro.

6) Kidney Problems

People who have kidney failure should refrain from using Mounjaro as it can cause their kidney problems to become worse.

7) Changes in Vision

If you notice a change in your vision during treatment with Mounjaro, you should contact your doctor to know if the symptoms could be due to this medication. 

Your doctor might ask you to stop using Mounjaro if the eye symptoms are suspected to be due to this drug in order to prevent the progression of the eye damage.

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Mounjaro’s Interactions with Other Drugs

Mounjaro delays gastric emptying, which may affect the absorption of other oral medications you are taking. Mounjaro can also interact with substances such as alcohol and medications.

Medications that are known to interact with Mounjaro include:

Mounjaro can also reduce the effectiveness of oral medications used for the treatment of: 

  • Clotting disorders, e.g. warfarin
  • Heart conditions, e.g. digoxin
  • Epilepsy, e.g. carbamazepine

Hence, patients using these medications should exercise caution while using Mounjaro. They can ask their doctor whether the doses of their current medications need to be changed to ensure optimum effectiveness. 

They can also consult a doctor to find an alternative medication for type 2 diabetes that they can use safely with their other medications.


Mounjaro is a prescription medication used for the treatment of type 2 diabetes.

Being aware of the contraindications of Mounjaro and drug interactions is important before you start using this medication in order to ensure you do not develop any adverse effects.

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  1. Gettman L. New Drug: Tirzepatide (Mounjaro). Sr Care Pharm. 2023 Feb 1;38(2):50-62. doi: 10.4140/TCP.n.2023.50. PMID: 36751934.
  2. Bezin J, Gouverneur A, Pénichon M, Mathieu C, Garrel R, Hillaire-Buys D, Pariente A, Faillie JL. GLP-1 Receptor Agonists and the Risk of Thyroid Cancer. Diabetes Care. 2023 Feb 1;46(2):384-390. doi: 10.2337/dc22-1148. PMID: 36356111.
  3. Delong C, Preuss CV. Box Warning. [Updated 2023 Jun 17]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan.
  4. Mishra R, Raj R, Elshimy G, Zapata I, Kannan L, Majety P, Edem D, Correa R. Adverse Events Related to Tirzepatide. J Endocr Soc. 2023 Jan 26;7(4):bvad016. doi: 10.1210/jendso/bvad016. PMID: 36789109; PMCID: PMC9915969. 

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