Ozempic Drug Interactions: Medications That React To Semaglutide

Ozempic is a medication used with diet and exercise to control blood sugar levels in individuals with type 2 diabetes. 

When one substance causes another to have an unexpected impact on another, this is known as a drug interaction. 

Continue reading to learn about drug and medication interactions with Ozempic (Semaglutide).

Drugs That Interact With Ozempic (Semaglutide)

Certain medications, vitamins, and alcohol may interact with ozempic.

1) Medications That Decrease Blood Sugar

When Ozempic is used with other medications that decrease blood sugar, you may experience a blood sugar drop.

This includes the following medications:

  • Insulin 
  • Sulfonylureas

Low blood sugar symptoms include headaches, dizziness, nausea, disorientation, sweating, and shakiness.

Your doctor may change your dosage of Ozempic or other medications, suggest frequent blood sugar checks, or advise you always to have a supply of glucose to avoid low blood sugar.

2) Other Drugs That Impact Your Blood Glucose

Other drugs that can affect your blood glucose level control include:

  • Birth control pills: used to prevent pregnancy.
  • Goserelin: used to prevent the synthesis of sex hormones like estrogen and testosterone.
  • Ethacrynic acid, Furosemide, and Indapamide: diuretics which increase your urine production to remove salt and water from your body.
  • Dobutamine, Dopamine, and Epinephrine: increase your blood flow by assisting your heart muscle in pumping efficiently.
  • Darunavir: used in the treatment of HIV/AIDS.
  • Daclatasvir: used to treat hepatitis C virus.
  • Chlorotrianisene, Diethylstilbestrol, and Drospirenone: used to treat prostate cancer and menopausal symptoms.
  • Ceritinib: used to treat lung cancer.
  • Cariprazine, Chlorpromazine, Clozapine, Fluphenazine, Iloperidone, and Ziprasidone: used to treat psychiatric diseases such as schizophrenia.
  • Corticosteroid such as Deflazacort, Hydrocortisone, Dexamethasone, and Cortisone.
  • Benzphetamine, Dexfenfluramine, Diethylpropion, Benzthiazide, and Fenfluramine: used to lose weight.
  • Bendroflumethiazide, Chlorothiazide, Chlorthalidone, and Diazoxide: used to treat high blood pressure.
  • Albuterol, Formoterol, Indacaterol, and Salmeterol: used to treat chest diseases such as asthma.
  • Gatifloxacin, Ciprofloxacin, Cinoxacin, Clarithromycin, Delafloxacin, Gemifloxacin, Enoxacin, Ofloxacin, and Isoniazid: antibiotics used to treat bacterial infections.

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3) Chromium supplements 

Semaglutide and the mineral chromium included in some supplements may interact together. 

Chromium may interact with Ozempic, potentially affecting blood sugar levels. Inform your doctor if you take chromium supplements, and they can adjust your dosage as needed.

4) Alcohol

Alcohol drinking with Ozempic can change your blood sugar levels and make it more difficult to control. 

It is recommended not to drink while taking this medication.


Ozempic medication usage has several drug and medication interactions. 

While there are potential interactions between Ozempic and certain medications, it does not necessarily mean they should never be used together. 

Your doctor will assess and adjust dosages accordingly

Consult your physician before using Ozempic. They may guide you on handling and monitoring your health while receiving Ozempic therapy. 

Inform your doctor whether you use cannabis, alcohol, any drugs, vitamins, herbs, and supplements.

Explore More

ozempic contraindications

Ozempic Contraindications: Who Should Not Take Semaglutide?


  1. Smits, M.M. and Van Raalte, D.H. (2021) ‘Safety of semaglutide,’ Frontiers in Endocrinology, 12. 
  2. Korsatko, S., Jensen, L., Brunner, M., Tarp, M. D., Holst, A. G., Heller, S. R., & Pieber, T. R. (2018). Effect of once‐weekly semaglutide on the counterregulatory response to hypoglycaemia in people with type 2 diabetes: A randomized, placebo‐controlled, double‐blind, crossover trial. Diabetes, Obesity & Metabolism, 20(11), 2565-2573. 
  3. Ozempic Drug Interactions Checker. Drugs.com
  4. Zinman, B. et al. (2019) ‘Efficacy, safety, and tolerability of oral semaglutide versus placebo added to insulin with or without metformin in patients with Type 2 diabetes: the PIONEER 8 trial,’ Diabetes Care, 42(12), pp. 2262–2271. 
  5. Winzeler, B. et al. (2020) ‘Effects of glucagon-like peptide-1 receptor agonists on fluid intake in healthy volunteers,’ Endocrine, 70(2), pp. 292–298. 

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