Exploring Why Mounjaro Causes Tiredness and Fatigue

Mounjaro is the newest anti-diabetes drug approved by the US FDA (Food and Drug Administration) for the management of type 2 diabetes. 

This medication is also used by obese and overweight patients to lose weight.

However, as with all medicines, Mounjaro can cause some side effects.

Weaknesses, fatigue, or feeling tired are some adverse effects reported by patients using Mounjaro.

We explore whether Mounjaro can make you feel tired and share some tips to help you avoid this side effect.

Does Mounjaro Make You Tired?

While there is limited conclusive evidence linking Mounjaro to tiredness or fatigue, it’s important to note that some individuals using this medication have reported feeling tired.

There is no data to establish that these side effects can be directly attributed to Mounjaro. They are suspected to be the result of some factors associated with diabetes.

For example, feeling tired and weak or having low energy are common symptoms associated with type 2 diabetes. 

Hence, it cannot be said with certainty that tiredness associated with the use of Mounjaro is caused by the medication.

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Potential Causes Linking Mounjaro and Tiredness

1) Rapid Weight Loss

Mounjaro belongs to a completely new class of drugs that activates both glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP).

GIP and GLP-1 stimulate hormones that control blood glucose levels and reduce appetite, thus improving diabetes control and triggering weight loss.

The double agonist approach of Mounjaro seems to cause people to lose more weight in a shorter duration than those who use single-agonist drugs. 

The sudden weight loss is one of the reasons why people might experience tiredness when using Mounjaro. 

2) Changes To Metabolic Processes

Mounjaro affects the body’s metabolic processes, which impacts the way your body produces and utilizes energy changes. 

This can disrupt the availability of energy to the body when you start using the drug, causing you to experience tiredness. 

These side effects are more likely to occur when Mounjaro is used in a higher dose. However, as the body gets used to the effect of Mounjaro, the energy levels become stable, allowing the side effects to subside.

3) Disrupts Hormones Leptin and Ghrelin

Another theory that attempts to explain fatigue in patients using Mounjaro is that this drug can disrupt the balance of hormones such as leptin and ghrelin involved in appetite regulation. 

These hormonal changes can reduce your appetite. This can lower your body’s energy reserves, thus causing a feeling of weakness and fatigue.

4) Psychological Factors

Psychological factors, such as stress and anxiety, can also impact your emotions and mood, potentially leading to ‘feeling low,’ which is often perceived as ‘feeling weak and tired.’


These theories explain the possible mechanisms that could lower your energy levels in the initial few days of using this drug or create a perception of feeling weak.

These side effects tend to vary among different patients and might be described as a general feeling of tiredness, reduced focus, loss of interest in any activity, lethargy, or drowsiness. 

Some patients also complain of an inability to perform routine tasks due to weakness and low energy levels.

You can talk to your doctor if you experience these symptoms to know if you need dosage adjustment to relieve the side effects and improve your energy levels.

Does Mounjaro Fatigue Go Away?

Yes, Mounjaro fatigue usually goes away within a few days to weeks of continued use as the body gets used to the effect of the medication.

However, if the symptoms persist or begin to interfere with your routine activities, you must talk to your doctor and discuss your concerns. 

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Here are some tips that will improve your energy levels and help you avoid Mounjaro fatigue:

  • Eat balanced and nutrient-dense meals that contain a combination of healthy fats, protein, and fiber.
  • Drink plenty of water to stay hydrated.
  • Practice mindful eating and pay attention to your body’s hunger or fullness cues.
  • Eat smaller meals at frequent intervals to ensure a steady supply of a source of energy to the body.
  • Engage in regular physical activity.
  • Practice relaxation techniques such as yoga and meditation to reduce stress and anxiety.

Does Mounjaro Give You Energy?

Mounjaro is designed to stimulate insulin production and increase glucose availability, potentially leading to increased energy over time.

However, individual responses may vary, and immediate effects on energy levels are not guaranteed.

However, these benefits of Mounjaro take time to become noticeable. As a result, you may experience weakness and fatigue for a few days when you start using this drug until your body gets used to the effects of the medications.


Some patients report experiencing tiredness as one of the side effects of Mounjaro. While the exact cause is not fully understood, various theories attempt to explain why some patients may experience weakness, low energy levels, and fatigue.

If you experience Mounjaro tiredness, you can try the tips to increase your energy levels so that you feel fresh and energetic and are able to perform your routine tasks with ease.

Explore More

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Vitamins For Energy: Ben’s Daily Energy Supplement.


  1. Seino Y, Yabe D. Glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1: Incretin actions beyond the pancreas. J Diabetes Investig. 2013 Mar 18;4(2):108-30. doi: 10.1111/jdi.12065. PMID: 24843641; PMCID: PMC4019264.
  2. Gettman L. New Drug: Tirzepatide (Mounjaro). Sr Care Pharm. 2023 Feb 1;38(2):50-62. doi: 10.4140/TCP.n.2023.50. PMID: 36751934.
  3. Shah M, Vella A. Effects of GLP-1 on appetite and weight. Rev Endocr Metab Disord. 2014 Sep;15(3):181-7. doi: 10.1007/s11154-014-9289-5. PMID: 24811133; PMCID: PMC4119845.

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