Why Am I Not Losing Weight On Ozempic?

Why am I not losing weight on Ozempic? Can Ozempic causes weight gain?

If you’ are wondering “why am i gaining weight on ozempic”, you’re in the right place.

One of the reasons Ozempic (semaglutide) has become a popular medication is its potential to promote significant weight loss. 

People with and without diabetes who want to lose weight are interested in medications like Ozempic, especially considering the majority of the United States population is considered overweight or obese.

Once you get a prescription for Ozempic, you might be puzzled when you’re not losing any weight. 

What are some of the common reasons you might not be losing weight on Ozempic, and how can you remedy them? Keep reading to find out.

Can Ozempic cause weight gain?

Taking Ozempic often results in weight loss, but there is a chance you can gain weight while taking it. According to the manufacturer of Ozempic, some people in clinical trials gained weight while taking Ozempic.

Ozempic isn’t commonly known to cause weight gain. You might gain weight while taking Ozempic due to reasons like diet changes, changes in physical activity, and taking other medications that cause weight gain.

Reasons for not losing weight on Ozempic

If you’ve been asking yourself, “Why am I not losing weight on Ozempic,” below are 7 possible reasons why.

1) You haven’t been taking it long enough

Ozempic medication duration matters! Sometimes it take weeks for Semaglutide to work. Those who are looking for Ozempic weight loss results in 6 weeks will need to take note on this.

The recommended dosing schedule is as follows: start at 0.25 milligrams once weekly for at least four weeks. 

After the first four weeks, your dose will be increased to 0.5 milligrams once weekly for another four weeks. 

The reason for this gradual increase is to help your body get used to the medication and help reduce potential side effects.

If your healthcare provider thinks you need a higher dose of Ozempic, they’ll recommend increasing your dose to 1 milligram weekly for four weeks. 

Then if that dose isn’t enough in terms of blood sugar control, your provider might increase your dose to a maximum of 2 milligrams weekly.

If you’re in the beginning stages of taking Ozempic, that could be one of the reasons you’re not losing weight. 

As you can tell from the schedule above, you might need to allow up to four months to even reach your goal dose. 

Then you’ll need to give yourself a few months at that dose to see how your body responds in terms of weight loss. So don’t panic on the potentially temporary weight gain on Ozempic.

2) You’re skipping doses

Once-weekly dosing of Ozempic is convenient compared to daily dosing of medications. 

However, that means that missing a dose can have a bigger impact on results (weight loss and blood sugar) since you’re only taking around four doses per month.

It doesn’t matter what time of day you take Ozempic, but you should aim to take it close to the same day each week (such as every Saturday, etc.). 


3) You’re constipated

One of the potential side effects of Ozempic is constipation. When you’re constipated, your body is holding on to waste longer than it should, which can literally weigh you down.

Promoting a healthy digestive system and bowel regularity can help offset constipation and might help you lose some weight if you’ve been constipated. Some ways to offset constipation are:

  • Eat plenty of fiber in the form of whole grains, fruits, vegetables, nuts, seeds, and legumes. You should be getting at least 25 grams of fiber per day.
  • Stay hydrated. Drinking enough fluids (especially water!) can help fiber do its job and promote bowel regularity. In fact, if you increase your fiber intake and don’t drink enough water, it can make your constipation worse!
  • Be physically active. This helps stimulate your digestive system and can help avoid constipation.

4) You’re not eating a healthy diet

It might be tempting to change nothing about your lifestyle and hope that Ozempic is enough to make you drop a lot of weight. 

That kind of mentality isn’t healthy and can promote unhealthy eating habits, which can harm more than your waistline over time.

You should think of Ozempic as one factor in your weight loss journey, not the only factor. 

Adopting healthy lifestyle habits while taking Ozempic can make it even more effective and help you lose more weight than if you rely on Ozempic alone to help you shed the pounds.

5) You’re not getting enough sleep

Sleep deprivation can wreak havoc on your metabolism and thwart weight loss efforts, which will also make you wonder why you are gaining weight on Ozempic.

According to a study, better sleep was associated with greater weight and fat loss compared to poor sleep.

If you feel like you’re getting enough sleep but are still tired during the day, you might want to be tested for obstructive sleep apnea (OSA). 

Sleep apnea affects people who are overweight or obese more than lean people, so if you’re taking Ozempic to lose weight, it’s worth asking your healthcare provider about it.

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6) Your stress level is high

High levels of stress can interrupt your sleep, lead to cravings, and can impair weight loss by increasing levels of the hormone cortisol. 

High levels of cortisol can increase your appetite and lead to weight gain.

7) You lead a sedentary lifestyle

If you’re not getting enough movement, it can make weight loss slow or stop. Being physically active boosts your metabolism (helps you burn more energy), improves insulin resistance (a condition that causes type 2 diabetes and can promote weight gain), and can help fight stress.

Having a sedentary office job, long commutes, or just not having a routine of being active might be one of the reasons you’re not losing weight on Ozempic.

8) You have hit a plateau

A weight loss plateau occurs when the rate of your weight loss notably decelerates or halts. In certain instances, your weight might even experience a minor increase during this plateau phase.

Encountering a slowing down on your weight loss progress is a common experience, particularly if you’re not dedicated to maintaining your muscle mass.

When you shed both muscle and fat, your metabolism decelerates, impeding the pace of your weight loss. However, as your body adapts, your weight loss expedition should recommence its momentum.

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4 ways to make Ozempic more effective

1) Eat a healthy diet

Aim to eat the kind of diet you’d follow to lose weight even if you weren’t taking Ozempic. 

Some changes that tend to be very effective at promoting weight loss include:

  • Cutting back on added sugars in the form of sugary drinks, desserts, and flavored foods like sweetened cereals, yogurts, etc.
  • Eating more meals at home and getting fast food, takeout, etc. less often.
  • Including a fruit or vegetable with each meal.
  • Practicing portion control and mindful eating by eating slowly and stopping when you feel satisfied, not just when your plate is empty.
  • Cutting down on greasy, fried foods, which are higher in calories compared to lean foods that are baked, broiled, steamed, etc.

2) Be physically active

Try to find an activity that you enjoy that keeps you active. Going for a walk with a coworker during your lunch break, taking your dog for a walk around the neighborhood when you get home, or going for a leisurely bike ride are all great ways to break up sedentary periods in your day.

Aim to be active for at least 30 minutes most days of the week to help promote weight loss while on Ozempic.

3) Be patient

It’s easy to get discouraged if you’re not losing weight as quickly as you’d like. Try to be patient with the process and remember that a healthy rate of weight loss is 1-2 pounds per week.

If you’re obsessing over the scale, it might be helpful to stop weighing yourself often and gauge your weight changes based on factors like how your clothes fit, how much energy you have, how your joints feel, and other indications that you might be losing weight.

4) Try to improve sleep hygiene and stress management.

Getting enough sleep at night and trying to offset the negative impacts of stress can be easier said than done. 

However, working towards these goals can improve not only your overall health and wellness but might help you lose more weight while on Ozempic.

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There are several reasons you might not be losing weight while on Ozempic, such as dosing issues, not allowing enough time, not practicing healthy lifestyle habits, high-stress levels, and not getting enough sleep.

Remedying some of these potential issues might help improve the rate of weight loss while on Ozempic. 

If you’re still stuck at a weight loss plateau after implementing the tips mentioned above, you should have a consultation with your healthcare provider to assess the next steps in supporting your weight loss goals.

Explore More

ozempic foods to avoid

What Foods To Eat & Avoid When Taking Ozempic (Semaglutide).


  1. Wilding JPH, Batterham RL, Calanna S, Davies M, Van Gaal LF, Lingvay I, McGowan BM, Rosenstock J, Tran MTD, Wadden TA, Wharton S, Yokote K, Zeuthen N, Kushner RF; STEP 1 Study Group. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021.
  2. Weghuber D, Barrett T, Barrientos-Pérez M, Gies I, Hesse D, Jeppesen OK, Kelly AS, Mastrandrea LD, Sørrig R, Arslanian S; STEP TEENS Investigators. Once-Weekly Semaglutide in Adolescents with Obesity. N Engl J Med. 2022.
  3. Semaglutide (Ozempic) for weight loss. Med Lett Drugs Ther. 2021.
  4. Kline CE, Chasens ER, Bizhanova Z, Sereika SM, Buysse DJ, Imes CC, Kariuki JK, Mendez DD, Cajita MI, Rathbun SL, Burke LE. The association between sleep health and weight change during a 12-month behavioral weight loss intervention. Int J Obes (Lond). 2021.
  5. Hewagalamulage SD, Lee TK, Clarke IJ, Henry BA. Stress, cortisol, and obesity: a role for cortisol responsiveness in identifying individuals prone to obesity. Domest Anim Endocrinol. 2016.

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