Switching from Ozempic to Mounjaro: Conversion Dose Chart

Ozempic (Semaglutide) and Mounjaro (Tirzepatide) are injectable medications to treat type 2 diabetes in adults. 

Both medications have become very popular for diabetes and weight loss.

Ozempic and Mounjaro are two different types of drugs, although they may have some similar features and effects. 

Many people want to know whether they can change from Ozempic to Mounjaro.

Keep reading to learn everything you need to know about switching from Ozempic to Mounjaro, including reasons people change medications, how to titrate safely, and considerations.

Can you switch from Ozempic to Mounjaro?

Yes. Switching from Ozempic to Mounjaro can be done under the guidance of your healthcare provider. 

Ozempic to Mounjaro conversion dose

Since Ozempic stays in your body for up to a week, you should only switch to Mounjaro after a full week. 

The dosages of Ozempic and Mounjaro are different and should be titrated under the supervision of your healthcare provider. 

Ozempic and Mounjaro doses are not equivalent, i.e., the Ozempic to Mounjaro conversion is 2 mg of Ozempic once weekly does not equal 2 mg of Mounjaro once weekly. 

Your healthcare provider will titrate the dose of Mounjaro according to your body’s response to it. 

Why do people change from Ozempic to Mounjaro?

There are many reasons why some people switch from Ozempic to Mounjaro. Common reasons include drug effectiveness, cost friendliness, and side effects tolerance. 

Drug effectiveness

Some people may not respond well to Ozempic. Your healthcare provider may advise accordingly based on your blood investigation results. 

If your blood sugar levels are still not satisfactory despite the increasing dose, they may suggest switching from Ozempic to another type of medication, such as Mounjaro. 

A recent study on Ozempic vs Mounjaro suggested that Mounjaro is more effective than Ozempic in improving HbA1c levels. 

Side effects

Ozempic and Mounjaro can cause similar side effects, primarily gastrointestinal (GI) disturbances. 

However, people may tolerate these side effects differently. Some people who are on Ozempic cannot tolerate the side effects caused by it. 

If that is the case for you, your healthcare provider may recommend switching from Ozempic to Mounjaro. 


The price for Mounjaro is slightly higher than Ozempic’s cost. However, some people may find the switch helpful if there is a change in their insurance coverage. 

Not only that, due to the surge in demand for Ozempic, some people may experience difficulties getting their hands on Ozempic. 

Hence, some may opt to switch from Ozempic to another type of anti-diabetes medication, such as Mounjaro. 

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Things to consider when switching from Ozempic to Mounjaro

Cost and insurance coverage

Both Ozempic and Mounjaro are undeniably expensive medications. You should clarify with your insurance provider if Mounjaro is covered before making the decision to switch. 


Mounjaro contains the active ingredient tirzepatide, as well as other ingredients like sodium phosphate dibasic heptahydrate, sodium chloride, and sodium hydroxide. You may be allergic to any of these ingredients. 

If you experience any signs and symptoms of an allergic reaction, you should consult your healthcare provider immediately. 

Contraindications to taking Mounjaro

You should inform your healthcare provider if you have a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia syndrome 2 (MEN-2) because Mounjaro is contraindicated in these cases.

Last dose of Ozempic

Ozempic takes about a week to clear out of your system. If you are making the switch from Ozempic to Mounjaro, make sure to inform your healthcare provider of your last dose of Ozempic so that they can plan your switching period properly. 

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How to safely titrate from Ozempic to Mounjaro

Here are some things you can do when you are considering switching from Ozempic to Mounjaro:

1) Consult your healthcare provider for alternative medications

If you have any concerns with your medication, you should discuss them with your healthcare provider. 

Your healthcare provider will evaluate your current medication regime, review your medical history, and assess how your body is responding to your current medications. 

They may review your blood sugar levels, HbA1C levels, side effects, and any other health conditions you may have. 

If indicated, they may initiate a switch to another type of medication, for example, Mounjaro. 

2) Follow the transition plan given by your healthcare provider

Based on your specific needs and medical history, your healthcare provider will recommend a new medication that may be more suitable for you.

Your healthcare provider will help to create a transition plan that outlines how to safely switch from your current medication to the new one. 

Your healthcare provider may also start you off with a lower dose of Mounjaro, although you were on a high dose of Ozempic. This is to minimize the risk of developing GI symptoms. 

They will then gradually increase the dose of Mounjaro while carefully monitoring your response to it until you’ve reached the therapeutic dose. You should not adjust the dose of your Mounjaro on your own.

Your healthcare provider will also advise you on directions to take the medication. If you have any questions regarding Mounjaro, you should clarify them with your healthcare provider during follow-up visits.

3) Report any side effects or allergic reactions to your healthcare provider

Once you have switched to Mounjaro, your healthcare provider will closely monitor your blood sugar levels and any potential side effects. 

They may also adjust the dosage of Mounjaro to ensure optimal control of your blood sugar levels. 

If you are experiencing any side effects while taking Mounjaro, you should inform your healthcare provider. 

If you start to develop any signs and symptoms of an allergic reaction, you should stop taking Mounjaro and inform your healthcare provider immediately. 

4) Do not take both Ozempic and Mounjaro at the same time

Taking both drugs together may lead to a sharp reduction of your blood sugar levels (hypoglycemia). This may lead to further complications such as heart problems, coma, and even death. 

Always follow your healthcare provider’s plan and clarify any doubts with them. 

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You may be considering switching from Ozempic to Mounjaro for various reasons, including achieving better blood sugar control, reducing side effects, and saving costs. 

It is safe to switch from Ozempic to Mounjaro, but it should be done under the supervision of your healthcare provider. 

Some things to consider before making the switch include cost and insurance coverage, allergies, and contraindications

You should not switch from Ozempic to Mounjaro on your own because it may lead to poorly controlled diabetes or hypoglycemia if the medication doses are incorrect. 

If you have discussed with your healthcare provider about switching from Ozempic to Mounjaro, it is important to follow the transition plan properly and communicate with your healthcare provider throughout the process. 

You should report any concerns, side effects, and allergic reactions you may experience while taking Mounjaro. 

If neither Ozempic nor Mounjaro works for you, your healthcare provider may recommend another type of medication to treat your type 2 diabetes.

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  1. Tichy, E. M., Hoffman, J. M., Suda, K. J., Rim, M. H., Tadrous, M., Cuellar, S., … & Schumock, G. T. (2022). National trends in prescription drug expenditures and projections for 2022. American Journal of Health-System Pharmacy, 79(14), 1158-1172.
  2. Chamberlin, S., & Dabbs, W. (2019). Semaglutide (ozempic) for type 2 diabetes mellitus. American Family Physician, 100(2), 116-117.
  3. Rebitch, C. B. (2023). Tirzepatide (Mounjaro) for the Treatment of Type 2 Diabetes Mellitus. American Family Physician, 108(1), 93.
  4. Frías, J. P., Davies, M. J., Rosenstock, J., Pérez Manghi, F. C., Fernández Landó, L., Bergman, B. K., … & Brown, K. (2021). Tirzepatide versus semaglutide once weekly in patients with type 2 diabetes. New England Journal of Medicine, 385(6), 503-515.
  5. Almandoz, J. P., Lingvay, I., Morales, J., & Campos, C. (2020). Switching between glucagon-like peptide-1 receptor agonists: rationale and practical guidance. Clinical Diabetes, 38(4), 390-402.

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