Prostate Medication

The Damaging Side Effects of Finasteride

A recent study has sent shock waves through the medical community.

Concerns about a popular drug used by millions of men have revealed a growing number of disturbing side effects.

The study revealed that finasteride( Proscar) – a popular drug for treating prostate symptoms and male pattern hair loss – causes alterations in the section of the brain responsible for processing long-term memory and emotional responses.

How does Finasteride work?

Finasteride is a 5-alpha-reductase inhibitor, meaning it prevents the enzyme 5-alpha-reductase from converting testosterone into DHT. It can be prescribed as tablets or as topical finasteride.

Prostate growth and size is largely dependent on DHT levels. There are two types of 5 αlpha-reductase; type 1, which is present in the tissue, such as liver or skin and type 2, which is the predominant type present in the prostate.

This enzyme is critical to the normal development of the prostate and hyperplastic growth later in life. Finasteride acts as an inhibitor of type 2 5α-reductase enzyme.

Finasteride does shrink the prostate and therefore appears to have some benefit. Further studies have indicated that it can also lower prostate-specific antigen PSA in some men.

The benefits are most visible for men with prostates larger than 40 g. It offers some symptomatic relief (approximately a 20% improvement over a year) by reducing the size of the prostate.

Studies have revealed that Finasteride propecia reduces intraprostatic DHT level by 91.4%. Despite the concerns about this substantial reduction, advocates and Merck have argued Finasteride(propecia) does not reduce DHT level so much as to castrate you chemically.

This is because circulating testosterone is converted to DHT by the type 1 isoenzyme, existing in the skin and liver. This being said, Finasteride might have the worst sexual side effects of all of the drugs examined in this report.

What are the side effects of Finasteride?

As well as causing alterations in the brain, Flomax can have many other adverse effects. These side effects include:

  • erectile dysfunction/ sexual dysfunction

  • loss of libido, penile shrinkage

  • insomnia

  • muscle atrophy

  • depression

  • lack of mental concentration

Post-Finasteride Syndrome: The Facts

The study, conducted by researchers at the University of Milano, revealed that finasteride ‘causes alterations’ in the section of the brain responsible for long-term processing memory and emotional responses.’

The animal model study, led by Roberto Cosimo Melcangi, Ph.D. at UM’s Department of Pharmacological and Biomolecular Sciences, showed several worrying consequences of using finasteride, including:

  • Long-term depressive-like behavior.

  • Alterations in neurogenesis, gliosis, and increased levels of inflammatory cytokines in the hippocampus.

  • Alterations in the composition of gut microbiota that was present one month after withdrawal of subchronic treatment of young male rats with finasteride.

  • Loss of libido, erectile dysfunction, Peyronie’s disease, penile shrinkage, gynecomastia, muscle atrophy, cognitive impairment, insomnia, severely dry skin, and tinnitus.

Researchers of the study believe this could be a breakthrough in better understanding Post-Finasteride Syndrome. “This is yet another example of the excellent research being conducted by Professor Melcangi and his team.

It brings us one critical step closer to better understanding the underlying biochemistry of PFS and–hopefully–to an effective treatment. We already know how to prevent the condition,” said John Santmann, MD, CEO of the Post-Finasteride Syndrome Foundation, which co-sponsored both studies.

Post Finasteride Syndrome

A 2014 meta-study coined the phrase “ Post Finasteride Syndrome, ”and noted that “Many clinicians are unaware of the scope of the persistent physical and psychological adverse effects of finasteride. Symptoms range from minor to severe.”

The meta-study examined 12 research papers that all showed high percentages (80-90+ percent) showing persistent and long-lasting sexual and psychological side effects.

This is a devastating, life-altering condition which can have an irreversible impact on both physical and mental health.

It has been attributed to job losses, the breakup of marriages and relationships, and in tragic cases, even suicide. In fact, by 2016, the World Health Organisation had recorded 59 suicides, as a result of the physical and physiological damage the drug can cause

Why does Finasteride continue to be sold?

Despite the evidence, Finasteride continues to be sold to men in various brand forms.

It is sold as both a solution to relieving symptoms of benign prostatic hyperplasia (BPH) and male balding. Health market research firm IQVIA says that approximately 570 million Finasteride tablets were dispensed in the United States alone between April 2017 and April 2018.

Merck, the pharmaceutical company that manufactures and sells finasteride, has stated: “We do not believe that reliable scientific evidence supports the existence of Post-Finasteride Syndrome. Merck stands behind the efficacy and safety profile of Propecia.”.

Yet despite this statement, over 1,4000 lawsuits have been filed against Merck in the United States and Canada since 2011.

These lawsuits have claimed permanent sexual problems, cognitive impairment, and depression. In 2012, the company was forced by the FDA to change the wording on Propecia labels regarding side effects from “temporary” to “persistent (see permanent).”

“Warning Labels Not Enough”

As a result of the latest Finasteride scandal, we reached out to prostate health expert and metabolic disease specialist Ben Ong for a breakdown of the latest research, and what other options men facing prostate disease have:

“As far back as 2008, European countries have been demanding updated warning labels on finasteride. But even they didn’t know the side effects were permanent.

The FDA only caved to pressure and put on those warning labels in 2012. But they didn’t say anything about ED, loss of libido or performance issues being permanent.

Talk on the inside is that the FDA might be considering recalling Finasteride depending on how the lawsuits play out.

The further development of Post-Finasteride Syndrome is greatly disturbing, and the dangerous effect and the tragic consequences in regard to men’s mental health should not be underestimated.”.

Can Finasteride cause cancer?

Previous clinical trials show that Proscar prevents low-grade cancer. But most of them, including long-term follow-up studies, show consistent results. Men who are taking it are more likely to have high-grade prostate cancer.

The link between Proscar and high-grade prostate cancer was first established by the landmark Prostate Cancer Prevention Trial (PCPT) in 2013.

The clinical trial showed that Finasteride increased the number of high-grade prostate cancers. This was even as it reduced patients’ overall risk for prostate cancer by 25%. As a result, the FDA added a black box warning to the drug as a result.

However, this question remains controversial.

New Research

Recent research has indicated that Finasteride reduces the risk of prostate cancer. Furthermore, it does not increase the risk of prostate cancer death. This was according to a presenter at the Annual American Urological Association Meeting in San Francisco.

In the Prostate Cancer Prevention Trial, researchers randomly assigned 18,882 men to receive Finasteride or placebo from 1993 to 1997. The intervention ended in 2003.

Thompson and colleagues matched participants from the Prostate Cancer Prevention Trial with records from the National Death Index (CDC-run database of death records). They reviewed the data of 300,000 people over a median follow-up of 18.4 years.

Among participants in the trial, 42 died of prostate cancer in the Finasteride group compared with 56 deaths in the placebo group.

From this most recent study, it seems that Finasteride does not increase the risk of high-grade prostate cancer. However, it is still worth bearing in mind the life-altering side effects that finasteride can have on your mental and physical health.

Finasteride causes cognitive & sexual decline

Thousands of men have had their lives ruined by this drug. For many, Finasteride medication has resulted in cognitive decline, causing brain fog and problems with memory and focus. For others, it has obliterated their sexual health, causing sexual side effects, including Peyronie’s disease and penile shrinkage.

Men who were searching for a solution to prostate health problems or male-pattern baldness have been exposed to an even greater number of health problems.

The number of men sharing their experience of Post-Finasteride Syndrome is steadily rising, painting a bleak picture of the life-shattering effects the drug can have.

With prostate cancer deaths overtaking that of breast cancer, it is important that the side effects of finasteride are known. Although the drug may offer short-term relief, the potential side effects are numerous.

How to shrink your prostate WITHOUT Finasteride or deadly side effects

To help men who have prostate disease or are concerned about their prostate health, we are offering readers exclusive limited time access to one of Ben’s special video presentations.

Normally reserved for private clients, we highly recommend that you watch this video while you still can. Especially if you have prostate disease, BPH, a high PSA, if you are a man over 50, or anyone who even knows a man over 50.

Discover the shocking truth about Flomax & Finasteride. Including, 5 deadly side effects of prostate drugs and why your doctor didn’t tell you about them, how and why Flomax & Finasteride are doing you more harm than good, and how you can improve your prostate health, side effect free, without using dangerous drugs and toxic treatments.


For more information on prostate cancer medication click here.


Sources

  1. Diviccaroa, S, Giattia, S, Borgob, F, Barcella, M, et al. (2019). Treatment of male rats with finasteride, an inhibitor of 5alpha-reductase enzyme, induces long-lasting effects on depressive-like behavior, hippocampal neurogenesis, neuroinflammation and gut microbio. Psychoneuroendocrinology. 99 (1), p206-215.
  2. Ganzer, C, Jacobs, A, Iqbal, F. (2014). Persistent Sexual, Emotional, and Cognitive Impairment Post-Finasteride: A Survey of Men Reporting Symptoms. American Journal of Men’s Health. 9 (3), p222–228.
  3. Kaufman KD, Olsen EA, Whiting D, Savin R, DeVillez R, Bergfeld W, et al. (1998). Finasteride in the treatment of men with androgenetic alopecia. Journal of the American Academy of Dermatology . 39 (4), p578–589.
  4. Melcangia, R, Santib, D, Spezzanoa, R, et al. (2017). Neuroactive steroid levels and psychiatric and andrological features in post-finasteride patients. The Journal of Steroid Biochemistry and Molecular Biology. 171 (1), p229-235.
  5. Mysore V. Finasteride and sexual side effects. Indian Dermatol Online J. 2012;3(1):62–65. doi:10.4103/2229-5178.93496https://www.pfsfoundation.org/news/finasterid-causes-several-alterations-in-the-section-of-the-brain/
  6. https://medium.com/s/story/my-life-has-been-ruined-by-an-anti-baldness-propecia-finasteride-side-effects-ed8b2fcd1e90https://www.lawyersandsettlements.com/lawsuit/propecia.htmlhttps://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/020788Orig1s020.pdf

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