What is the Best Supplement for an Enlarged Prostate? [2021]

Trying to find a prostate supplement that actually works isn’t easy. There are so many to choose from, it’s difficult to know where to start. But many men swear by prostate health supplements and find their symptoms improve by taking them.

Because BPH (benign prostatic hyperplasia) causes the prostate gland to enlarge, it can cause prostate problems such as weak urine flow, or frequent urination throughout the day or at night.

Your doctor will normally prescribe a prescription drug as a treatment. But these drugs tend to come with adverse effects which many men would rather avoid. That’s why choosing the best prostate supplement for you may offer a natural alternative for men who would rather not depend on medication.

Why Take a Prostate Supplement?

Preventing a disease is always superior to treating disease, especially in the case of a complex disease such as prostate cancer.

A large body of research can be found on both in vitro (in a laboratory) and in vivo (in the live subject) of preventative prostate cancer measures.

Some of these strategies include consumption of protein, carbohydrates, fats, fiber, vegetable extracts and other solid products and combinations of these in the diet, vitamins, minerals, and biologically active substances.

A randomized, double-blind, placebo-controlled crossover study in men with prostate cancer was performed. This study used a dietary supplement to examine levels of prostate-specific antigen.

Past studies that have been conducted showed significant relationships between dietary supplementation and the incidence and mortality of prostate cancer. 49 patients participated in the study.

They all had a history of prostate cancer and had rising prostate-specific antigen levels after radical prostate removal or radiation therapy. The supplement used in this experiment consisted of lycopene and other antioxidants as the main ingredients.

The researchers found that the slowly rising prostate-specific antigen levels that the participants came in with started regressing after taking a dietary supplement.

Saw palmetto is a commonly used herb in the field of natural prostate health. One study reviewed the current research on the efficacy of saw palmetto specifically for Benign Prostatic Hyperplasia.

They looked at it as a monotherapy (single drug regimen) as well as in combination with other therapies.

Their research was primarily based on a Cochrane review, which is sort of a “gold standard” in the medical research world, as they have lots of valid and reliable research in their library.

The study concluded that using saw palmetto in conjunction with lycopene, selenium, and stinging nettle had positive results.

Patients generally had a favorable response to treatment and a positive clinical experience overall.

The study concluded that there are several early positive studies that are promising in the use of saw palmetto, especially now that we know more about its effects in the body.

It is also good to know that it does have potential synergistic effects when combined with other natural supplements and therapies.

As we have mentioned here several times, BPH is becoming increasingly common.

Typical treatment would normally include the use of a1-adrenergic receptor antagonists and 5a-reductase inhibitors. These drugs have indeed been found to be useful for Benign Prostatic Hyperplasia.

However, the side effects associated with their use are leading patients and practitioners alike to turn elsewhere for solutions. Surgery is relatively common in the management of prostate health as well.

This is invasive, costly, and risky as well, and therefore, it cannot be used as a routine treatment method.

What ingredients are found in prostate health supplements?

• Some of the most effective prostate supplements contain quercetin, which is a bioflavonoid.
  
  
  
• Another effective ingredient is rye or Secale cornutum. The rye extract called cernitin is the active ingredient that has a positive effect on the prostate gland.
  
  
  
• One of the most well-known prostate supplements is Serenoa repens, commonly known as saw palmetto.
  
  
  
• Although lesser-known, another effective supplement ingredient is Epilobium parviflorum. Selenium is a micronutrient that is essential for proper prostate health.
  
  
  
• Lycopene is a compound found in tomatoes that is greatly helpful for the prostate gland’s health. A supplement called Pygeum africanum has also proven useful in improving the performance of the prostate.~~
  
  
• Beta-sitosterol is a nutrient that is in many prostate supplement products, and for good reason: it is effective in helping to decrease the size of the prostate in those with Benign Prostatic Hyperplasia.
  
  
  
• Urtica dioica, commonly known as stinging nettle, is an effective herb that can improve prostate health as well.
  
  
  
• Finally, Cucurbita pepo and its extracts are proven to be useful in prostate supplements too.

Benefits of Prostate Supplements

A variety of natural remedies for enlarged prostate can also provide relief from urinary symptoms. They could sometimes slow down the progression of BPH, too. In some cases, we can consume them from natural sources. In other cases, they are only available as extracts and supplements.

Some have anti-inflammatory potential, while others have an antioxidant effect. Some of them act directly on the prostate gland, while others have an indirect action by modulating our metabolism and hormones.

Quality

The FDA has provided good manufacturing practices (GMPs) for dietary supplements. This helps ensure dietary supplements contain the labeled ingredients with purity, accurate composition, and the stated strength.

Numerous companies also offer third-party testing and provide a seal of approvals for products that pass their tests.

This offers assurance that the product contains the ingredients listed on the label, and does not contain harmful levels of contaminants.

Safety

Some herbal supplements are contaminated with pesticides or toxic heavy metals. Some manufacturers adulterate supplements with prescription drugs that are undeclared on their labels.

For example, some supplements marketed for sexual function contain Viagra or Cialis. While some prostate supplements contain alpha-blockers like Terazosin.

Ingesting excessive amounts of some herbal extracts can result in acute liver injury or even failure.

Herbal and dietary supplements account for 10% of drug-induced liver injury cases in the USA (Crescioli, 2018). Green tea and Garcinia cambogia, in particular, have been linked with liver side effects (Sarma, 2008; Cresciol, 2018i; Navarro, 2013).

Efficacy

The FDA requires manufacturers of dietary supplements to detail the amount of each ingredient in their products on the “Supplement Facts” label. However, there is a regulatory loophole that allows manufacturers to cluster ingredients together with a “proprietary blend.”

The manufacturer only has to label the total amount of the blend rather than the quantities of each ingredient. Supplement companies use this loophole to cut costs, rather than providing you with the optimal dosages of each ingredient.

Many brands label each individual ingredient quantity. But this does not guarantee clinically relevant doses.

For example, some saw palmetto supplements offer less than 320 mg per day and contain as low as 40% fatty acids so they will be ineffective (Habib, 2004). Saw palmetto extracts should be standardized to at least 85% fatty acids and 0.2% sterols.

Ben’s Natural Health supplements are based on the most current, published, peer-reviewed scientific research. We do the research work for you, so you don’t have to.

What are the top prostate vitamins?

Vitamin D

Vitamin D deficiency in middle-aged men has been associated with moderate to severe urinary symptoms.

Cell culture studies demonstrate that vitamin D reduces inflammation when it binds to the Vitamin D Receptor in the prostate (Penna 2009, Comeglio, 2010). Thus vitamin D may play a role in preventing BPH.

Randomized control trials have not been conducted to see the effects of vitamin D supplementation on BPH and urinary symptoms in men.

However, a randomized control trial in females with overactive bladder reported positive effects of vitamin D supplementation (Oberg, 2017).

Selenium

Selenium is an essential trace mineral that plays important roles in reproduction, thyroid hormone metabolism, DNA synthesis, and protection from oxidative damage and infection.

Food sources include Brazil nuts, organ meats, and seafood. Selenium quantity in plant foods depends on selenium levels in the soil.

An observational study in Europe found that men with high selenium levels in their nails were less likely to develop prostate cancer. Men with high selenium levels with prostate cancer were less likely to have aggressive prostate cancer (Allen, 2016).

A human clinical trial provided 30 middle-aged men with 200 micrograms of selenium supplementation for 6 weeks. There was an increase in the antioxidant glutathione peroxidase and a reduction in PSA (Zhang, 2011).

Another human clinical trial studied the effects of 240 micrograms selenium with 570 milligrams milk thistle in men with BPH. After 6 months, urine flow rate and IPSS ratings improved and reduced PSA (Vostalova, 2013).

What are the best herbs for the prostate?

Saw Palmetto

Saw palmetto is the most commonly used herbal supplement for treating lower urinary tract symptoms.

The clinical research on saw palmetto has displayed mixed results. Some studies show saw palmetto improves urinary function (Vela-Navarette, 2018), while some research reports saw palmetto is ineffective (MacDonald, 2012).

The reason for this discrepancy is likely due to differing product quality. Brands containing more than 80% of fatty acids show improved urinary function.

Saw palmetto extracts with more than 80% fatty acids inhibits 5AR enzymes more effectively than extracts with less than 80% (Scaglione , 2008).

Pygeum

A study found that pygeum africanum extracts inhibited the growth of human prostate cancer cells in a test tube study. Also, mice were fed either Pygeum africanum or casein for a period of 5 months.

Pygeum africanum significantly reduced the incidence of prostate cancer. 35% of the mice that were fed Pygeum africanum developed prostate cancer and 62.5% of the casein-fed mice developed prostate cancer (Shenouda et al., 2007).

A review of 17 double-blinded studies examined the effects of pygeum africancum for treating BPH (Ishani, 2000). The study found that patients were 35% more likely to show symptom improvement. There was also a reduction in urinary retention, improved urine flow and a reduction in night time incontinence.

Pumpkin Seed

Pumpkin seed contains fatty acids, phytosterols, tocopherols, and micronutrients. These ingredients have anti-inflammatory effects and reduce the prostate volume in preclinical research.

Animal research shows pumpkin seed extract prevented the development of BPH and increased the testosterone: estrogen ratio (Ejike, 2011).

A one-year randomized controlled trial compared the effects of pumpkin seed to placebo in men with BPH (Vahlensieck, 2015). By the end of the study, the men receiving pumpkin seed reported greater improvement in subjective reporting of symptoms and reduced nocturia.

Both groups improved the urination flow rate, with no difference between the two (Vahlensieck, 2015).

What are the most effective ingredients for prostate health?

Beta-sitosterol

Beta-sitosterol exists in rice bran, wheat germ, peanuts, corn oils, and soybeans. Herbal extracts like saw palmetto, rye grass pollen, pygeum africanum, and stinging nettles contain beta-sitosterol.

These plant sterols are used for treating BPH and beta-sitosterol may be the key ingredient.

Clinical trials show beta-sitosterol increases the maximum urinary flow rate by about 45% and men report improved urinary symptoms (Wilt, 1993). Beta-sitosterol works by inhibiting 5-alpha-reductase and reducing inflammation by inhibiting prostaglandin production (Lowe, 1996).

Ryegrass pollen

Honeybees make a lump of pollen that they have collected from flowers. Bees use the pollen to feed their larvae and as material for producing royal jelly. Pollen is a natural source of antioxidants, amino acids, fatty acids, vitamins and minerals (Rzepecka-Stojko, 2015).

Pollen extract may improve urinary function by relaxing smooth muscle tone and increasing bladder muscle contraction (Kimura, 1986) and/or relaxing sphincter muscles (Nakase, 1988).

Pollen extract may improve nocturia (waking up regularly at night to urinate) (MacDonald, 2000). Pollen extract also increases the maximum flow rate and decreases residual urine volume (Murakami, 2008). Men require at least 120 mg of pollen extract per day.

Stinging nettle

Stinging nettle contains compounds like beta-sitosterol, lignins, and polysaccharides.

Preclinical studies show stinging nettle causes anti-inflammatory and antioxidant effects that may relieve the symptoms of BPH (Chrubasik et al., 2007).

Some studies show that 360-600 mg of stinging nettle per day improves the peak urinary flow rate and reduces prostate volume when compared to placebo. However, stinging nettle has no effect on PSA levels (Men, 2016). The higher end of the dose range may be required to reduce prostate volume.

Zinc

Zinc is an essential mineral found in a number of foods. Oysters contain more zinc per serving than any other food, but red meat and poultry provide the majority of zinc in the American diet.

Other good food sources include beans, nuts, certain types of seafood (like crab and lobster), and whole grains.

The prostate gland contains a high level of zinc, which is reduced when prostate cancer manifests (Györkey; Costello). A study in mice showed that zinc suppressed human prostate tumor growth by preventing the expression of the androgen receptor (To 2018).

Other natural ingredients with potential for prostate health

Lycopene

Lycopene is an antioxidant that gives tomatoes its red color. A randomized control trial examined the effects of lycopene extract in men with BPH (Moazzami, 2011). Men were given 15 mg of lycopene per day or a placebo for 6 months.

PSA was significantly reduced in the lycopene group and prostate volume was unchanged after 6 months. Prostate volume increased by 24% in the placebo group (Landberg, 2010). However, some studies have reported no effect of lycopene supplementation (Schwarz, 2008).

Tomato intake providing about 30 mg of lycopene reduces PSA in men with prostate cancer (Chen, 2001; Paur, 2017).

These benefits were exerted from lycopene from whole foods rather than as an extract. It is likely that lycopene from whole foods exerts health benefits than may not occur with an extract. 

Green Tea

Prostate cancer mortality is lowest in Asia, where they also drink 20% of the world’s green tea (Klotz, 2005).

When Asians move to the west Green tea intake reduces and prostate cancer mortality increases (Ito, 2014). Preclinical studies show compounds in green tea called catechins can protect against cancerous tumor growth (Klotz, 2005).

Human clinical studies have had mixed results. For example, men with prostate cancer were given either green tea or a placebo for 12 months (Micali, 2017).

By the end of the study, there were no differences in prostate cancer rates between the groups.

Quality of life and urinary tract symptoms also did not improve (Micali, 2017). Although one study found green tea improved subjective BPH symptoms (Bettuzzi, 2006).

Boron

Boron is a trace element in the human diet. Rich food sources of boron include fruits, nuts, legumes, vegetables, and wine.

An epidemiological study found that people with a greater dietary boron intake were at a lower risk of developing prostate cancer (Cui, 2004).

Test tube studies have shown boric acid can inhibit the growth of prostate cancer cells (Gallardo-Williams 2004; Pizzorno, 2015).

Quercetin

Quercetin is a flavonoid found in high concentrations in capers, and red onion (Paulis, 2018).

Preclinical research demonstrates that quercetin can protect against chronic prostatitis by reducing inflammation and oxidative stress (Cai, 2009).

A human clinical trial showed that 1 gram of quercetin daily for 4 weeks significantly improved the symptoms of chronic non-bacterial prostatitis (Meng, 2018).

Another human clinical study showed that taking quercetin alongside curcumin, saw palmetto and antibiotics was more effective at treating chronic bacterial prostatitis than taking antibiotics alone (Shoskes, 1999).

90% of the men that took the supplement with antibiotics did not experience an infection recurrence, while only 27% of men than took antibiotic did not have an infection recurrence (Shoskes, 1999).  

For quercetin to be effective quercetin you would require either a high dose (1 gram per day) or a lower dose when combined with other ingredients like curcumin and saw palmetto.

Curcumin

Curcumin is the bioactive ingredient in the Indian spice turmeric. Curcumin is known for its antioxidant and anti-inflammatory effects and may protect against prostate diseases (Guo, 2013).

Inflammation molecules promote the growth of prostatic epithelial cells and contribute to the development of prostate enlargement (Taoka, 2017). Higher levels of inflammation are associated with more severe LUTS (Mickel, 2016).

Curcumin supplementation reduces the prostate volume in an animal model (Kim, 2015) and is associated with improved urinary symptoms in men with BPH after 2 to 6 months (Cosentino, 2016, Ledda, 2012).

Another study provided men with a high PSA with 1 gram of curcumin and 300 mg of beta-sitosterol for 30 days. 

PSA dropped from 6.48 to 4.65 and many of the men avoided unnecessary biopsies (Fabiani, 2018). However, studies have yet to compare curcumin with a placebo.

Top 9 prostate supplements for men 2021

Total Health for the Prostate

Total Health for the Prostate contains a total of 23 all-natural ingredients, including clinically significant dosages of beta-sitosterol, quercetin, pomegranate extract, boron, and turmeric. Many of the nutrients included in Total Health have been shown in clinical trials to improve urine flow, reduce frequent urination, and lower your PSA score.

Formulated with powerful vitamins, minerals, and nutrients, Total Health works to lower DHT levels and reduce the size of the prostate gland.

Hormonal balance plays a vital role in men’s health. When levels of estrogen increase at the same time that testosterone levels decrease, estrogen dominance can occur. This causes testosterone to be converted into dihydrotestosterone (DHT).

DHT is a highly active form of testosterone that irritates the prostate and can cause prostate enlargement and inflammation.

Therefore, by reducing DHT levels, Total Health for the Prostate helps to combat the root causes of prostate disease and inflammation, in order to restore your health.

Total Health for the Prostate also contains a broad range of minerals and vitamins to help support your general health, working as both a multivitamin and effective prostate supplement.

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Prostate Healer

Prostate Healer is a safe, proprietary, unique blend of the world’s 9 most powerful prostate healing and rejuvenating herbs. Concentrated extracts of these herbs have been blended into a powerful and effective tincture.

Each ingredient has been thoroughly researched and scientifically proven to improve and maintain prostate health.

Punarnava, for example, has been shown to improve urinary symptoms associated with BPH and inhibit prostate growth.

It has been formulated to effectively combat BPH and prostatitis and provide symptomatic relief from urgency, frequency, and nocturia. It works on the prostate, kidney, and bladder simultaneously, coaxing cells gently to resume normal function.

By this action, you’re fighting against prostatitis and BPH If you’re like many men that use the formula, you’ll see a reduction in the number of times you get up to go to the bathroom to urinate, plus see an improvement in the flow of your urine.

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Prost-P10x

Prost-P10x contains many of the key ingredients for prostate support, including vitamin D3, zinc, pygeum, and stinging nettle. However, the majority of these extracts are in low doses. Further, it contains a much lower dose of beta-sitosterol compared to the cheaper, less effective saw palmetto. But it contains clinically significant amounts of quercetin and zinc, two essential extracts for a healthy prostate.

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Super Beta Prostate

Super Beta Prostate contains just 13 ingredients, and so a much smaller range of vitamins and minerals. It lacks common and vital ingredients including quercetin and turmeric which have both been clinically shown to improve prostatitis symptoms and support a healthy prostate. Vitamin C was also missing from the formula. Vitamin C is essential for boosting the immune system and protecting your body from the damaging effects of free radicals. These antioxidants help to stabilize these free radicals which reduce your chance of developing cancer. A good prostate supplement should include a good mix of antioxidants to help support a healthy immune system to assist with prostate symptoms.

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Ultra Natural Prostate

Ultra Natural Prostate contains 11 ingredients, most of which have been clinically found to provide prostate-specific benefits, including beta-sitosterol, pumpkin oil, and pygeum bark. However, the doses provided are too small to be clinically effective. Ultra Natural Prostate contains just 180 mg of beta-sitosterol, and 200 mg of pumpkin oil, whereas typically prostate supplements require a much higher dose to treat symptoms of prostate disease. Even though these are good ingredients with fantastic benefits for prostate health, in such small doses, it is possible that men may not get the results they are looking for.

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Prostara

Prostara contains some important prostate-specific ingredients, including beta-sitosterol, zinc, saw palmetto and pumpkin seed. However out of those, only saw palmetto meets the recommended clinical dosage for prostate health and support. It also has an issue with poor ingredients quality given many of the ingredients not present in the most bioavailable form which reduces effectiveness in the body. Prostara does include some ingredients which are capable of relieving urinary and bladder problems.

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Prostacet

Prostacet is missing some of the most important staple ingredients commonly found in prostate supplements including boron, beta-sitosterol, and quercetin. Only 4 ingredients mention the dosage included, all of which are much lower than the recommended daily allowance. It contains a proprietary blend of 10 ingredients, which may sound like an effective way to receive nutrients however, men’s health supplements use such blends to hide the specific quantity and quality of ingredients. In short, while Prostacet does contain some reliable and clinically supported ingredients for prostate health, the doses are mostly unspecified, meaning those included probably only trace amounts.

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Optiprostate XTS

OptiProstate XTS includes saw palmetto and pumpkin oil, both of which have been shown to improve prostate health. However, in total, the formulation contains just four ingredients, two of which are not directly beneficial for prostate health. It lacks most of the essential vitamins and minerals typically found in high-quality prostate supplements. For the ingredients which are beneficial for prostate health, the doses were too low, and would not produce any meaningful effects for long-term prostate improvement.

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Urinozinc

Urinozinc is a commonly available prostate supplement that you can generally find on the shelf at Walmart or your local pharmacy. It is missing the broad spectrum of vitamins and minerals that are essential to improving and maintaining prostate health. And many of the ingredients in Urinozinc are not included in clinically significant dosages.

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The issue with supplements

Dietary supplements go through less regulatory hurdles than drugs. Drugs must undergo clinical trials to demonstrate to the FDA that they are safe and effective.

The FDA can then approve the new drug, so it can be marketed and sold in the US. However, safety issues are detected with a third of drugs after market approval.

Dietary supplements are considered safe until proven otherwise. Manufacturers are not obligated to conduct clinical trials to prove the efficacy and safety before entering the market.

Brands are free to make a number of health claims related to addressing nutrient deficiencies, supporting general health or supporting a particular body function (e.g. immunity or heart health).

The manufacturers just need to follow the claim with the following message: “This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.”

What is the best natural prostate supplement?

Total Health for the Prostate contains 23 all-natural ingredients, including beta-sitosterol, curcumin, quercetin, boron, and zinc.

It is the only health supplement that contains clinically significant doses of all the active nutrients your prostate needs.

The individual ingredients were also chosen based on studies that show their synergistic properties. Meaning that taking the individual ingredients together is more effective than taking them individually.

For more information on Total Health for the Prostate and how it can improve your urinary symptoms, click the button below.